Sirt2 sirtuin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sirt2provided by MGI
Official Full Name: sirtuin 2provided by MGI
Primary source: MGI:MGI:1927664
See related: Ensembl:ENSMUSG00000015149 AllianceGenome:MGI:1927664
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sir2l; SIR2L2; 5730427M03Rik
Summary: Enables NAD-dependent protein lysine deacetylase activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including positive regulation of cell cycle process; regulation of gene expression; and regulation of protein metabolic process. Acts upstream of or within several processes, including negative regulation of NLRP3 inflammasome complex assembly; regulation of fat cell differentiation; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in several structures, including brain; liver; oocyte; sensory organ; and spinal cord. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 56.8), cerebellum adult (RPKM 53.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.92 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28466192..28488086)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28766752..28788665)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dynamics and necessity of SIRT1 for maternal-zygotic transition.
Title: Dynamics and necessity of SIRT1 for maternal-zygotic transition.
m[6]A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/Sirt2 Axis.
Title: m(6)A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/Sirt2 Axis.
The SIRT2-AMPK axis regulates autophagy induced by acute liver failure.
Title: The SIRT2-AMPK axis regulates autophagy induced by acute liver failure.
The role of NAD-dependent deacetylase sirtuin-2 in liver metabolic stress through regulating pyruvate kinase M2 ubiquitination.
Title: The role of NAD-dependent deacetylase sirtuin-2 in liver metabolic stress through regulating pyruvate kinase M2 ubiquitination.
Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis.
Title: Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis.
Spinal sirtuin 2 attenuates bone cancer pain by deacetylating FoxO3a.
Title: Spinal sirtuin 2 attenuates bone cancer pain by deacetylating FoxO3a.
Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice.
Title: Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice.
Oligodendrocyte-derived exosomes-containing SIRT2 ameliorates depressive-like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT/GSK-3beta pathway in depressed mice.
Title: Oligodendrocyte-derived exosomes-containing SIRT2 ameliorates depressive-like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT/GSK-3β pathway in depressed mice.
Sirtuin 2 up-regulation suppresses the anti-tumour activity of exhausted natural killer cells in mesenteric lymph nodes in murine colorectal carcinoma.
Title: Sirtuin 2 up-regulation suppresses the anti-tumour activity of exhausted natural killer cells in mesenteric lymph nodes in murine colorectal carcinoma.
Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model.
Title: Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model.

Submit: New GeneRIF Correction See all GeneRIFs (135)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sirt2 (e-PCR), detects polymorphism
- UniSTS:531293

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein demyristoylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein demyristoylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein depalmitoylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein depalmitoylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K14 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K18 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K56 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, NAD-dependent	ISO Inferred from Sequence Orthology more info
enables histone H4K16 deacetylase activity, NAD-dependent	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity, NAD-dependent	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity, NAD-dependent	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein lysine deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables tubulin deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tubulin deacetylase activity	ISO Inferred from Sequence Orthology more info
enables tubulin deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of NLRP3 inflammasome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to caloric restriction	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to epinephrine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chromatin organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in myelination in peripheral nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of NLRP3 inflammasome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte progenitor proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte progenitor proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of striated muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-lysine deacetylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of attachment of spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-translational protein modification	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in rDNA heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tubulin deacetylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within tubulin deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tubulin deacetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	IDA Inferred from Direct Assay more info	PubMed
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in juxtaparanode region of axon	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral loop	ISO Inferred from Sequence Orthology more info
located_in lateral loop	ISS Inferred from Sequence or Structural Similarity more info
located_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in myelin sheath	HDA more info	PubMed
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in myelin sheath abaxonal region	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in paranodal junction	IDA Inferred from Direct Assay more info	PubMed
located_in paranodal junction	ISO Inferred from Sequence Orthology more info
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info
located_in paranode region of axon	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in terminal loop	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-2

Names: NAD-dependent deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; SIR2-like protein 2; mSIR2L2; regulatory protein SIR2 homolog 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2

NP_001116237.1

EC 2.3.1.286

NP_001116238.1

EC 2.3.1.286

NP_071877.3

EC 2.3.1.286

XP_036009218.1

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122765.2 → NP_001116237.1 NAD-dependent protein deacetylase sirtuin-2 isoform 2

See identical proteins and their annotated locations for NP_001116237.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is 37 aa shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AC171210

Consensus CDS

CCDS85253.1

UniProtKB/TrEMBL

A0A140LHL5, Q3UJK6

Related

ENSMUSP00000147217.2, ENSMUST00000122915.8

Conserved Domains (1) summary

cd01408
Location:40 → 294

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001122766.2 → NP_001116238.1 NAD-dependent protein deacetylase sirtuin-2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks multiple in-frame exons in the 5' coding region, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC171210

Consensus CDS

CCDS52165.1

UniProtKB/TrEMBL

A0A140LHL5, Q3UJK6

Related

ENSMUSP00000132783.2, ENSMUST00000170068.9

Conserved Domains (1) summary

cd01408
Location:7 → 261

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
NM_022432.5 → NP_071877.3 NAD-dependent protein deacetylase sirtuin-2 isoform 1

See identical proteins and their annotated locations for NP_071877.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC171210

Consensus CDS

CCDS21055.1

UniProtKB/Swiss-Prot

E9PXF5, Q8VDQ8, Q9CXS5, Q9EQ18, Q9ERJ9, U5TP50

UniProtKB/TrEMBL

A0A140LHL5, Q3UJK6

Related

ENSMUSP00000072732.5, ENSMUST00000072965.5

Conserved Domains (1) summary

cd01408
Location:77 → 331

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

28466192..28488086

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153325.1 → XP_036009218.1 NAD-dependent protein deacetylase sirtuin-2 isoform X1

UniProtKB/TrEMBL

A0A140LHL5, Q3UJK6

Conserved Domains (1) summary

cd01408
Location:40 → 294

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...