Nfyb nuclear transcription factor-Y beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfybprovided by MGI
Official Full Name: nuclear transcription factor-Y betaprovided by MGI
Primary source: MGI:MGI:97317
See related: Ensembl:ENSMUSG00000020248 AllianceGenome:MGI:97317
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cbf-A
Summary: Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; early conceptus; genitourinary system; and nervous system. Orthologous to human NFYB (nuclear transcription factor Y subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 15.1), CNS E14 (RPKM 12.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 40.25 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (82584534..82599985, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (82748700..82764151, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study indentifies NF-Yb as a novel transcriptional regulator of Gria4 (GluA4 gene), and a controller of excitotoxic death in the oligodendroglial lineage; describes a novel regulatory region within Gria4 containing CCAAT sequences whose binding by NF-Yb is regulated by excitotoxicity. Excitotoxicity-induced alterations in NF-Yb binding are associated with changes in Gria4 transcription.
Title: NF-Y-dependent regulation of glutamate receptor 4 expression and cell survival in cells of the oligodendrocyte lineage.
deletion of CBF-B activated expression of specific endoplasmic reticulum stress-regulated genes. Inactivation of CBF-B also inhibited expression of C/EBP alpha, an important transcription factor controlling metabolic processes in adult hepatocytes
Title: Inactivation of CBF/NF-Y in postnatal liver causes hepatocellular degeneration, lipid deposition, and endoplasmic reticulum stress.
CBF-A is a novel transacting factor required for cytoplasmic mRNA transport and localization
Title: In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences.
p73 and DeltaNp73 behave as physiological regulators for recruitment of histone deacetylase to NF-Y and transcription of the PDGFRB promoter
Title: p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA985999 (e-PCR)
- UniSTS:165715

16.MMHAP35FRF7.seq (e-PCR)
- UniSTS:123304

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of CCAAT-binding factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CCAAT-binding factor complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-DNA complex	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: nuclear transcription factor Y subunit beta

Names: CAAT box DNA-binding protein subunit B; NF-YB; nuclear transcription factor Y subunit B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428686.1 → NP_001415615.1 nuclear transcription factor Y subunit beta isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC155709

UniProtKB/Swiss-Prot

P63139, Q3UK54
NM_001428687.1 → NP_001415616.1 nuclear transcription factor Y subunit beta isoform b

Status: VALIDATED

Source sequence(s)

AC155709
NM_010914.3 → NP_035044.1 nuclear transcription factor Y subunit beta isoform a

See identical proteins and their annotated locations for NP_035044.1

Status: VALIDATED

Source sequence(s)

AC155709

Consensus CDS

CCDS48654.1

UniProtKB/Swiss-Prot

P63139, Q3UK54

UniProtKB/TrEMBL

Q9D056

Related

ENSMUSP00000122403.2, ENSMUST00000130911.8

Conserved Domains (1) summary

pfam00808
Location:57 → 122

CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

82584534..82599985 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243380.3 → XP_011241682.1 nuclear transcription factor Y subunit beta isoform X2

Conserved Domains (1) summary

pfam00808
Location:2 → 47

CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
XM_011243379.4 → XP_011241681.1 nuclear transcription factor Y subunit beta isoform X1

Conserved Domains (1) summary

pfam00808
Location:57 → 122

CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
XM_011243381.4 → XP_011241683.1 nuclear transcription factor Y subunit beta isoform X2

See identical proteins and their annotated locations for XP_011241683.1

Conserved Domains (1) summary

pfam00808
Location:2 → 47

CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone