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    Gtpbp3 GTP binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 70359, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gtpbp3provided by MGI
    Official Full Name
    GTP binding protein 3provided by MGI
    Primary source
    MGI:MGI:1917609
    See related
    Ensembl:ENSMUSG00000007610 AllianceGenome:MGI:1917609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410009F13Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 16.6), adrenal adult (RPKM 15.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gtpbp3 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71938788..71952268)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71486144..71499624)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E358 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene anoctamin 8 Neighboring gene STARR-positive B cell enhancer ABC_E2868 Neighboring gene plasmalemma vesicle associated protein Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like Neighboring gene STARR-seq mESC enhancer starr_21821 Neighboring gene STARR-positive B cell enhancer ABC_E1759 Neighboring gene bone marrow stromal cell antigen 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102372

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tRNA modification GTPase GTPBP3, mitochondrial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032544.4NP_115933.2  tRNA modification GTPase GTPBP3, mitochondrial precursor

      See identical proteins and their annotated locations for NP_115933.2

      Status: VALIDATED

      Source sequence(s)
      AC127416
      Consensus CDS
      CCDS40384.1
      UniProtKB/Swiss-Prot
      Q58E73, Q923K4, Q99M99
      UniProtKB/TrEMBL
      B2RRS4
      Related
      ENSMUSP00000007754.7, ENSMUST00000007754.13
      Conserved Domains (3) summary
      cd04164
      Location:248416
      trmE; trmE is a tRNA modification GTPase
      PRK05291
      Location:35492
      trmE; tRNA modification GTPase TrmE; Reviewed
      pfam10396
      Location:35152
      TrmE_N; GTP-binding protein TrmE N-terminus

    RNA

    1. NR_157144.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127416
    2. NR_157145.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127416
      Related
      ENSMUST00000095259.10
    3. NR_157146.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK046330, BY287260, BY588239
    4. NR_157147.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC055716, BY287260
      Related
      ENSMUST00000127741.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71938788..71952268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509737.4XP_006509800.1  tRNA modification GTPase GTPBP3, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006509800.1

      Conserved Domains (1) summary
      PRK05291
      Location:35323
      trmE; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE

    RNA

    1. XR_379045.4 RNA Sequence