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    Pdcl phosducin-like [ Mus musculus (house mouse) ]

    Gene ID: 67466, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pdclprovided by MGI
    Official Full Name
    phosducin-likeprovided by MGI
    Primary source
    MGI:MGI:1914716
    See related
    Ensembl:ENSMUSG00000009030 AllianceGenome:MGI:1914716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PhLP1; 1200011E13Rik
    Summary
    Involved in positive regulation of smoothened signaling pathway. Acts upstream of or within heterotrimeric G-protein complex assembly and visual perception. Predicted to be located in cilium. Predicted to be active in cytoplasm. Orthologous to human PDCL (phosducin like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.6), CNS E14 (RPKM 11.9) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pdcl in Genome Data Viewer
    Location:
    2 B; 2 24.19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37240086..37249832, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37350074..37359820, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 22306 Neighboring gene STARR-seq mESC enhancer starr_04311 Neighboring gene olfactory receptor family 5 subfamily C member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4441 Neighboring gene STARR-seq mESC enhancer starr_04312 Neighboring gene STARR-positive B cell enhancer ABC_E7813 Neighboring gene ring finger and CCCH-type zinc finger domains 2 Neighboring gene STARR-seq mESC enhancer starr_04313 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene STARR-positive B cell enhancer ABC_E1244 Neighboring gene STARR-positive B cell enhancer ABC_E11130 Neighboring gene STARR-positive B cell enhancer ABC_E4442 Neighboring gene zinc finger and BTB domain containing 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosducin-like protein
    Names
    PHLP
    NP_080452.2
    XP_006498315.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026176.3NP_080452.2  phosducin-like protein

      See identical proteins and their annotated locations for NP_080452.2

      Status: VALIDATED

      Source sequence(s)
      AK028668, AV286628, BY024444
      Consensus CDS
      CCDS15998.1
      UniProtKB/Swiss-Prot
      Q3TKI0, Q9DBX2
      UniProtKB/TrEMBL
      Q3UZN6
      Related
      ENSMUSP00000009174.9, ENSMUST00000009174.15
      Conserved Domains (1) summary
      pfam02114
      Location:35299
      Phosducin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      37240086..37249832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498252.1XP_006498315.1  phosducin-like protein isoform X1

      See identical proteins and their annotated locations for XP_006498315.1

      UniProtKB/Swiss-Prot
      Q3TKI0, Q9DBX2
      UniProtKB/TrEMBL
      Q3UZN6
      Conserved Domains (1) summary
      pfam02114
      Location:35299
      Phosducin