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    Itgav integrin alpha V [ Mus musculus (house mouse) ]

    Gene ID: 16410, updated on 3-Dec-2024

    Summary

    Official Symbol
    Itgavprovided by MGI
    Official Full Name
    integrin alpha Vprovided by MGI
    Primary source
    MGI:MGI:96608
    See related
    Ensembl:ENSMUSG00000027087 AllianceGenome:MGI:96608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik
    Summary
    This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]
    Expression
    Ubiquitous expression in placenta adult (RPKM 13.0), ovary adult (RPKM 12.9) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Itgav in Genome Data Viewer
    Location:
    2 D; 2 49.33 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (83554796..83637261)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (83722303..83806917)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene STARR-seq mESC enhancer starr_04984 Neighboring gene STARR-seq mESC enhancer starr_04985 Neighboring gene STARR-positive B cell enhancer ABC_E11141 Neighboring gene STARR-positive B cell enhancer ABC_E11142 Neighboring gene STARR-positive B cell enhancer ABC_E7831 Neighboring gene STARR-positive B cell enhancer mm9_chr2:83505584-83505885 Neighboring gene zinc finger CCCH-type containing 15 Neighboring gene STARR-seq mESC enhancer starr_04989 Neighboring gene DNA methyltransferase 3-like, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2039 Neighboring gene STARR-positive B cell enhancer ABC_E7832 Neighboring gene family with sequence similarity 171, member B Neighboring gene STARR-positive B cell enhancer ABC_E11143 Neighboring gene zinc finger SWIM-type containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to C-X3-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to C-X3-C chemokine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellular matrix protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibronectin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to insulin-like growth factor I binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to neuregulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to neuregulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to opsonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein kinase C binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transforming growth factor beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apolipoprotein A-I-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apolipoprotein A-I-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic cell clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic cell clearance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic cell clearance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of molecule of bacterial origin TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fertilization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in focal adhesion assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in gonad morphogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of entry of bacterium into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of entry of bacterium into host cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipoprotein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of low-density lipoprotein receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of low-density lipoprotein receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of macrophage derived foam cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of bone resorption TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of phagocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to nitric oxide TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in symbiont entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transforming growth factor beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in trophoblast giant cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing, spreading of epidermal cells NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of alphav-beta3 integrin-HMGB1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of alphav-beta3 integrin-HMGB1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of integrin alphav-beta1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrin alphav-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alphav-beta3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alphav-beta3 complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of integrin alphav-beta5 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of integrin alphav-beta5 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alphav-beta6 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of integrin alphav-beta6 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alphav-beta8 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alphav-beta8 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    integrin alpha-V
    Names
    alpha v integrin
    vitronectin receptor alpha polypeptide (VNRA)
    vitronectin receptor subunit alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398691.1NP_001385620.1  integrin alpha-V isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL772301
      UniProtKB/TrEMBL
      A0A0F7IQ06
      Conserved Domains (4) summary
      smart00191
      Location:366420
      Int_alpha; Integrin alpha (beta-propellor repeats)
      sd00039
      Location:125182
      7WD40; WD40 repeat [structural motif]
      pfam08441
      Location:466909
      Integrin_alpha2; Integrin alpha
      pfam13517
      Location:220270
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
    2. NM_008402.4NP_032428.2  integrin alpha-V isoform 1 precursor

      See identical proteins and their annotated locations for NP_032428.2

      Status: REVIEWED

      Source sequence(s)
      AL772301
      Consensus CDS
      CCDS16181.1
      UniProtKB/Swiss-Prot
      A2AKI6, P43406
      UniProtKB/TrEMBL
      A0A0F7IQ06
      Related
      ENSMUSP00000028499.5, ENSMUST00000028499.11
      Conserved Domains (3) summary
      smart00191
      Location:367421
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:467910
      Integrin_alpha2; Integrin alpha
      sd00039
      Location:126183
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      83554796..83637261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)