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    dgt5 dim gamma-tubulin 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36364, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgt5provided by FlyBase
    Official Full Name
    dim gamma-tubulin 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0033740
    Locus tag
    Dmel_CG8828
    See related
    AllianceGenome:FB:FBgn0033740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8828; Dgt5; Dmel\CG8828; msd2
    Summary
    Enables protein-macromolecule adaptor activity. Involved in mitotic spindle assembly; mitotic spindle-templated microtubule nucleation; and regulation of mitotic nuclear division. Located in spindle. Part of HAUS complex. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dgt5 in Genome Data Viewer
    Location:
    49A7-49A7; 2-67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12465678..12471775, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8353183..8359280, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Dystrobrevin Neighboring gene uncharacterized protein Neighboring gene Lachesin Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 10 Neighboring gene Diuretic hormone 44 receptor 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Direct observation of branching MT nucleation in living animal cells. Verma V, et al. J Cell Biol, 2019 Sep 2. PMID 31340987, Free PMC Article
    2. A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes. Wainman A, et al. Genes Dev, 2009 Aug 15. PMID 19684111, Free PMC Article
    3. γ-TuRCs and the augmin complex are required for the development of highly branched dendritic arbors in Drosophila. Mukherjee A, et al. J Cell Sci, 2024 May 1. PMID 38606636, Free PMC Article
    4. Wac: a new Augmin subunit required for chromosome alignment but not for acentrosomal microtubule assembly in female meiosis. Meireles AM, et al. J Cell Biol, 2009 Mar 23. PMID 19289792, Free PMC Article
    5. Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle. Chen JWC, et al. Biol Open, 2017 May 15. PMID 28351835, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic spindle assembly IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HAUS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dim gamma-tubulin 5
    Names
    CG8828-PA
    CG8828-PB
    dgt5-PA
    dgt5-PB
    mitotic spindle density 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12465678..12471775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136941.3 → NP_610785.1  dim gamma-tubulin 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610785.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K4B4
      Related
      FBpp0087059
      Conserved Domains (1) summary
      cl25732
      Location:38 → 454
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_001299420.1 → NP_001286349.1  dim gamma-tubulin 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286349.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K4B4
      Conserved Domains (1) summary
      cl25732
      Location:38 → 454
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4B4.1 Q7K4B4

    Gene LinkOut

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