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    vih vihar [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vihprovided by FlyBase
    Official Full Name
    viharprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264848
    Locus tag
    Dmel_CG10682
    See related
    AllianceGenome:FB:FBgn0264848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1105/01; anon-WO0172774.54; anon-WO0172774.55; anon-WO0172774.56; CG10682; Dmel\CG10682; l(3)S110501; UbcH10
    Summary
    Enables ubiquitin conjugating enzyme activity. Involved in several processes, including anaphase-promoting complex-dependent catabolic process; exit from mitosis; and positive regulation of mitotic metaphase/anaphase transition. Located in nucleus. Part of ubiquitin conjugating enzyme complex. Colocalizes with spindle pole centrosome. Is expressed in organism. Orthologous to human UBE2C (ubiquitin conjugating enzyme E2 C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vih in Genome Data Viewer
    Location:
    69C4-69C4; 3-38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12504292..12505821)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12497392..12498921)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43868 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sticky Neighboring gene long non-coding RNA:CR45168 Neighboring gene trailer hitch

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2. Nagy O, et al. Cell Div, 2012 Mar 14. PMID 22417125, Free PMC Article
    2. The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis. Braun AL, et al. Open Biol, 2021 Jun. PMID 34186008, Free PMC Article
    3. Mitosis: a matter of getting rid of the right protein at the right time. Pines J. Trends Cell Biol, 2006 Jan. PMID 16337124
    4. The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation. Máthé E, et al. Curr Biol, 2004 Oct 5. PMID 15458643
    5. Identification of a physiological E2 module for the human anaphase-promoting complex. Williamson A, et al. Proc Natl Acad Sci U S A, 2009 Oct 27. PMID 19822757, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vihar E2 ubiquitin-conjugating enzyme contributes to the spatiotemporal control of Cyclin B degradation that first occurs at the spindle poles in mitosis.
      Title: The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin conjugating enzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vihar
    Names
    CG10682-PA
    lethal (3) S110501
    vih-PA
    NP_648582.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12504292..12505821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140325.3 → NP_648582.1  vihar [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTY6
      Related
      FBpp0075690
      Conserved Domains (2) summary
      COG5078
      Location:31 → 166
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:36 → 172
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTY6.1 Q9VTY6

    Gene LinkOut

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