FoxP Forkhead box P [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: FoxPprovided by FlyBase
Official Full Name: Forkhead box Pprovided by FlyBase
Primary source: FLYBASE:FBgn0262477
Locus tag: Dmel_CG43067
See related: AllianceGenome:FB:FBgn0262477
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG16899; CG32937; CG43067; dFoxP; Dmcg16899; Dmel\CG43067; DmFoxP; fd85E
Old locus tag: Dmel_CG16899; Dmel_CG32937
Summary: Enables protein homodimerization activity. Involved in locomotion; male courtship behavior, veined wing generated song production; and operant conditioning. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; ganglia; larval nervous system; and protocerebral bridge. Used to study specific developmental disorder. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; autism spectrum disorder (multiple); autoimmune disease (multiple); communication disorder (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including FOXP1 (forkhead box P1); FOXP2 (forkhead box P2); and FOXP4 (forkhead box P4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85E5-85E5; 3-49 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9726020..9730872, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5551742..5556401, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wings of Change: aPKC/FoxP-dependent plasticity in steering motor neurons underlies operant self-learning in Drosophila.
Title: Wings of Change: aPKC/FoxP-dependent plasticity in steering motor neurons underlies operant self-learning in Drosophila.
conserved regulation of neurodevelopmental processes and behavior
Title: Conserved regulation of neurodevelopmental processes and behavior by FoxP in Drosophila.
FoxP mutants are deficient in operant self-learning
Title: Drosophila FoxP mutants are deficient in operant self-learning.
Results provide the first functional characterization of FoxP2 in invertebrates (FoxP) and suggest an intriguing homology with this crucial human speech and language gene
Title: Conserved role of Drosophila melanogaster FoxP in motor coordination and courtship song.
FoxP mutants took longer than wild-type flies to form decisions of similar or reduced accuracy, especially in difficult, low-contrast tasks.
Title: FoxP influences the speed and accuracy of a perceptual decision in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior, veined wing generated song production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in operant conditioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: forkhead box P

Names: CG43067-PC; CG43067-PD; CG43067-PE; FoxP-PC; FoxP-PD; FoxP-PE; forkhead domain 85E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

9726020..9730872 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260082.3 → NP_001247011.1 forkhead box P, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247011.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6N2, E0WMM3

Conserved Domains (2) summary

cd00059
Location:328 → 400

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:157 → 224

FOXP-CC; FOXP coiled-coil domain
NM_001104256.4 → NP_001097726.1 forkhead box P, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097726.1

Status: REVIEWED

UniProtKB/TrEMBL

E0WMM2, Q4V6X1, Q9VH87

Conserved Domains (2) summary

cd00059
Location:328 → 400

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:157 → 224

FOXP-CC; FOXP coiled-coil domain
NM_001316572.1 → NP_001303501.1 forkhead box P, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUS5, K4ENJ1

Conserved Domains (2) summary

pfam16159
Location:157 → 224

FOXP-CC; FOXP coiled-coil domain

cl00061
Location:328 → 373

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...