ato atonal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: atoprovided by FlyBase
Official Full Name: atonalprovided by FlyBase
Primary source: FLYBASE:FBgn0010433
Locus tag: Dmel_CG7508
See related: AllianceGenome:FB:FBgn0010433
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: At; Ato; ATO; ato1; ato[Dm]; bHLHa10; CG7508; Dmel\CG7508
Summary: Enables protein heterodimerization activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including eye morphogenesis; nervous system development; and regulation of gene expression. Located in nucleus. Is expressed in several structures, including brain; chordotonal organ; embryonic head segment; imaginal disc; and somatic precursor cell. Human ortholog(s) of this gene implicated in persistent hyperplastic primary vitreous. Orthologous to human ATOH7 (atonal bHLH transcription factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 84F6-84F6; 3-48 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8278052..8279274)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4103774..4104996)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Daughterless level sets Emc protein levels in most cells, apparently by stabilizing Emc in heterodimers. Emc is destabilized in proneural regions by local competition for heterodimer formation by proneural bHLH proteins including Atonal or AS-C proteins.
Title: Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners.
the regulation of ato expression in the Bolwig's organs primordium, was examined.
Title: Distinct regulation of atonal in a visual organ of Drosophila: Organ-specific enhancer and lack of autoregulation in the larval eye.
three binding sites are essential for atonal induction in the posterior ocelli, but show considerable redundancy in the anterior ocellus. this difference parallels the distinct control of ato transcription in the posterior and anterior progenitors of the developing compound eyes.
Title: Shared and distinct mechanisms of atonal regulation in Drosophila ocelli and compound eyes.
genetic ablation of Atonal Olfactory receptor neurons (ORNs) affects antennal lobe structure and axon targeting of Amos ORNs.
Title: Hierarchical axon targeting of Drosophila olfactory receptor neurons specified by the proneural transcription factors Atonal and Amos.
Data show that eyes absent protein (Eya) is required in late progenitors to promote eye formation, and that failure to induce the target gene atonal and consequent lack of neuron formation.
Title: ato-Gal4 fly lines for gene function analysis: Eya is required in late progenitors for eye morphogenesis.
atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers
Title: Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers.
Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
Title: Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
findings suggest a role for the non-bHLH portion of Ato proteins in modulating the function of the bHLH domain in eye neurogenesis and implicate specific aa residues of the bHLH in this process
Title: Identification of Bombyx atonal and functional comparison with the Drosophila atonal proneural factor in the developing fly eye.
lilli contributes to ato auto-regulation in the morphogenetic furrow by first regulating the expression of da prior to ato.
Title: Drosophila lilliputian is required for proneural gene expression in retinal development.
Ato and Sens selectively enhance abdominal SOP development in a Spitz-independent manner, suggesting additional genetic interactions between this proneural pathway and Abd-A.
Title: Proneural and abdominal Hox inputs synergize to promote sensory organ formation in the Drosophila abdomen.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Bolwig's organ morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in R8 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antennal joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antennal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insect visual primordium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior, veined wing generated song production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in neuron fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oenocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEP Inferred from Expression Pattern more info	PubMed
involved_in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: atonal

Names: CG7508-PA; ato-PA; atona

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

8278052..8279274

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169213.2 → NP_731223.1 atonal [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731223.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0AQ36, A0AQ37, A0AQ43, P48987, Q9VHU0

UniProtKB/TrEMBL

C0MKM7, C0MKM8

Related

FBpp0081318

Conserved Domains (1) summary

cd00083
Location:253 → 312

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...