Nup54 Nucleoporin 54kD [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nup54provided by FlyBase
Official Full Name: Nucleoporin 54kDprovided by FlyBase
Primary source: FLYBASE:FBgn0033737
Locus tag: Dmel_CG8831
See related: AllianceGenome:FB:FBgn0033737
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8831; Dmel\CG8831; nup54; NUP54
Summary: A structural constituent of nuclear pore. Involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore central transport channel. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm. Human ortholog(s) of this gene implicated in dystonia 37, early-onset with striatal lesions. Orthologous to human NUP54 (nucleoporin 54). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12428449..12431099, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8315954..8318604, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Channel nuclear pore complex subunits are required for transposon silencing in Drosophila.
Title: Channel nuclear pore complex subunits are required for transposon silencing in Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear pore organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleocytoplasmic transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain