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    jagn jagunal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jagnprovided by FlyBase
    Official Full Name
    jagunalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037374
    Locus tag
    Dmel_CG10978
    See related
    AllianceGenome:FB:FBgn0037374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10978; Dmel\CG10978; Jagn
    Summary
    Involved in several processes, including establishment of ER localization; oocyte growth; and vitellogenesis. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic ventral epidermis; and gland. Human ortholog(s) of this gene implicated in severe congenital neutropenia 6. Orthologous to human JAGN1 (jagunal homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See jagn in Genome Data Viewer
    Location:
    83C3-83C3; 3-47.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5779315..5781308)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1605037..1607030)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Decapping enzyme, scavenger Neighboring gene Secretory 8 Neighboring gene uncharacterized protein Neighboring gene katanin p60-like 1 Neighboring gene Histone acetyltransferase 1 Neighboring gene Regulatory particle non-ATPase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The endoplasmic reticulum is partitioned asymmetrically during mitosis before cell fate selection in proneuronal cells in the early Drosophila embryo. Eritano AS, et al. Mol Biol Cell, 2017 Jun 1. PMID 28381427, Free PMC Article
    2. JAGN1, tetraspanins, and Erv proteins: is common topology indicative of common function in cargo sorting? VanWinkle PE, et al. Am J Physiol Cell Physiol, 2020 Oct 1. PMID 32783652, Free PMC Article
    3. Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. Lee S, et al. J Cell Biol, 2007 Mar 26. PMID 17389229, Free PMC Article
    4. Networks that link cytoskeletal regulators and diaphragm proteins underpin filtration function in Drosophila nephrocytes. Muraleedharan S, et al. Exp Cell Res, 2018 Mar 15. PMID 29458174, Free PMC Article
    5. A docked mutation phenocopies dumpy oblique alleles via altered vesicle trafficking. Kandasamy S, et al. PeerJ, 2021. PMID 34721959, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A deficiency screen of the 3rd chromosome for dominant modifiers of the Drosophila ER integral membrane protein, Jagunal.
      Title: A deficiency screen of the 3rd chromosome for dominant modifiers of the Drosophila ER integral membrane protein, Jagunal.
    2. JAGN1, tetraspanins, and Erv proteins: is common topology indicative of common function in cargo sorting?
      Title: JAGN1, tetraspanins, and Erv proteins: is common topology indicative of common function in cargo sorting?
    3. We propose that ER reorganization is an important mechanism used by cells to prepare for an increased demand for membrane traffic, and Jagunal facilitates this process through ER clustering.
      Title: Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of ER localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vitellogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    jagunal
    Names
    CG10978-PA
    CG10978-PB
    jagn-PA
    jagn-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5779315..5781308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169103.2 → NP_731002.1  jagunal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731002.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K1V5
      UniProtKB/TrEMBL
      E2QD00
      Related
      FBpp0078273
      Conserved Domains (1) summary
      pfam07086
      Location:1 → 188
      Jagunal; Jagunal, ER re-organization during oogenesis

    2. NM_141328.3 → NP_649585.1  jagunal, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K1V5
      UniProtKB/TrEMBL
      E2QD00
      Related
      FBpp0078274
      Conserved Domains (1) summary
      pfam07086
      Location:1 → 188
      Jagunal; Jagunal, ER re-organization during oogenesis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QD00 E2QD00
    Q7K1V5.1 Q7K1V5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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