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    CkIIalpha casein kinase IIalpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48448, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CkIIalphaprovided by FlyBase
    Official Full Name
    casein kinase IIalphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264492
    Locus tag
    Dmel_CG17520
    See related
    AllianceGenome:FB:FBgn0264492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0958/08; alphaCK2; anon-WO02059370.53; Cask-II-a; CG17520; CJIIalpha; CK II; CK-2; CK-II; CK-II alpha; CK2; CK2 alpha; CK2-alpha; CK2a; ck2alpha; Ck2alpha; CK2alpha; CkII; CKII; CKII alpha; CKII-alpha; CkIIa; CKIIa; CKIIalfa; ckIIalpha; CKIIalpha; dCK2alpha; dCKII; dCKII alpha; Dm-CK2-alpha; DmCK2alpha; DmCKIIalpha; Dmel\CG17520; l(3)S095808; Tik
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including lateral inhibition; locomotor rhythm; and positive regulation of smoothened signaling pathway. Located in cytosol and nucleus. Part of protein kinase CK2 complex. Is expressed in adult head; adult heart; adult s-LNv neurons; and spermatozoon. Orthologous to several human genes including CSNK2A1 (casein kinase 2 alpha 1) and CSNK2A3 (casein kinase 2 alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CkIIalpha in Genome Data Viewer
    Location:
    80D1-80D1; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (23097072..23103460)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (23090172..23096560)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene neuromusculin Neighboring gene Ribosomal protein L10 Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the catalytic subunit of casein kinase II expressed in Escherichia coli and regulation of activity. Lin WJ, et al. J Biol Chem, 1991 Mar 25. PMID 1900838
    2. Inhibition of caries in hamsters treated with staphylococcin 1580. Fitzgerald RJ, et al. Infect Immun, 1986 Nov. PMID 3770944, Free PMC Article
    3. Purification and characterization of a type II casein kinase from Drosophila melanogaster. Glover CV, et al. J Biol Chem, 1983 Mar 10. PMID 6298230
    4. SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression. Zwarts L, et al. Dis Model Mech, 2017 Jun 1. PMID 28331058, Free PMC Article
    5. Casein kinase II beta-subunit inhibits the activity of the catalytic alpha-subunit in the absence of salt. Tiganis T, et al. Biochim Biophys Acta, 1993 Dec 8. PMID 8268212

    See all (206) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data (including data from studies using transgenic animals) suggest that catalytic activity of casein kinase 2 (CkIIa/CkIIb) is essential for oogenesis in this species; Jabba, a lipid droplet-associated protein and substrate for casein kinase 2, is essential in modulating ovarian lipid metabolism. (CkIIa = casein kinase II alpha subunit; CkIIb = casein kinase II beta subunit)
      Title: The protein kinase CK2 substrate Jabba modulates lipid metabolism during Drosophila oogenesis.
    2. CK2alpha might be important in regulating synaptic plasticity by modulating the transcription of BRP. Hence, we propose that CK2alpha is a novel regulator of the active zone protein, BRP, in Drosophila.
      Title: CK2α regulates the transcription of BRP in Drosophila.
    3. Coexpressing CK2alpha and CK2beta increases Smo accumulation and induces ectopic Hh target gene expression.
      Title: Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus.
    4. overexpression of Tik elicits ectopic bristles in N(+) flies and suppresses the retinal defects of the gain-of-function allele N(spl).
      Title: Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis.
    5. Results describe the isolation of temperature-sensitive alleles of Drosophila CK2alpha.
      Title: Drosophila protein kinase CK2 is rendered temperature-sensitive by mutations of highly conserved residues flanking the activation segment.
    6. Coimmunoprecipitation experiments revealed that the alpha-subunit of the protein kinase CK2 (CK2alpha) was associated with soluble Stellate.
      Title: Genetically Derepressed Nucleoplasmic Stellate Protein in Spermatocytes of D. melanogaster interacts with the catalytic subunit of protein kinase 2 and carries histone-like lysine-methylated mark.
    7. Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.
      Title: Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.
    8. casein kinase II has a role in regulating cAMP-response element-binding protein DNA binding by phosphorylation at specific CK sites
      Title: Phosphorylation of conserved casein kinase sites regulates cAMP-response element-binding protein DNA binding in Drosophila.
    9. CK2 alpha binds and phosphorylates ribosomal protein L22
      Title: Interaction of casein kinase II with ribosomal protein L22 of Drosophila melanogaster.
    10. Sequencing of full-length cDNA encoding subunits in platelets and megakaryocytic cells
      Title: Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular mRNA localization involved in pattern specification process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lateral inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte dorsal/ventral axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oocyte dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    casein kinase IIalpha
    Names
    CG17520-PA
    CG17520-PB
    CG17520-PC
    CG17520-PD
    CG17520-PE
    CG17520-PF
    CG17520-PG
    CkIIalpha-PA
    CkIIalpha-PB
    CkIIalpha-PC
    CkIIalpha-PD
    CkIIalpha-PE
    CkIIalpha-PF
    CkIIalpha-PG
    NAP1-kinase
    alpha subunit of drosophila casein kinase II
    casein kinase 2
    casein kinase II
    casein kinase II alpha
    casein kinase II alpha subunit
    casein kinase II-alpha subunit
    lethal (3) S095808
    protein kinase CK2
    timekeeper
    NP_001036624.1
    NP_001287151.1
    NP_001287152.1
    NP_001287153.1
    NP_524918.1
    NP_730774.1
    NP_730775.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      23097072..23103460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300224.1 → NP_001287153.1  casein kinase IIalpha, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287153.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08181, Q0E8B4, Q9W5T2
      UniProtKB/TrEMBL
      A4V2B8
      Conserved Domains (1) summary
      cd14132
      Location:18 → 322
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    2. NM_001043159.3 → NP_001036624.1  casein kinase IIalpha, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036624.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08181, Q0E8B4, Q9W5T2
      UniProtKB/TrEMBL
      A4V2B8
      Conserved Domains (1) summary
      cd14132
      Location:18 → 322
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    3. NM_080179.5 → NP_524918.1  casein kinase IIalpha, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08181, Q0E8B4, Q9W5T2
      UniProtKB/TrEMBL
      A4V2B8
      Related
      FBpp0070042
      Conserved Domains (1) summary
      cd14132
      Location:18 → 322
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    4. NM_168985.2 → NP_730774.1  casein kinase IIalpha, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730774.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08181, Q0E8B4, Q9W5T2
      UniProtKB/TrEMBL
      A4V2B8
      Related
      FBpp0070041
      Conserved Domains (1) summary
      cd14132
      Location:18 → 322
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    5. NM_168986.2 → NP_730775.1  casein kinase IIalpha, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730775.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08181, Q0E8B4, Q9W5T2
      UniProtKB/TrEMBL
      A4V2B8
      Related
      FBpp0070043
      Conserved Domains (1) summary
      cd14132
      Location:18 → 322
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    6. NM_001300222.1 → NP_001287151.1  casein kinase IIalpha, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287151.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08181, Q0E8B4, Q9W5T2
      UniProtKB/TrEMBL
      A4V2B8
      Conserved Domains (1) summary
      cd14132
      Location:18 → 322
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    7. NM_001300223.1 → NP_001287152.1  casein kinase IIalpha, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287152.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08181, Q0E8B4, Q9W5T2
      UniProtKB/TrEMBL
      A4V2B8
      Conserved Domains (1) summary
      cd14132
      Location:18 → 322
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V2B8 A4V2B8
    P08181.2 P08181

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