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    Zdhhc8 Zinc finger DHHC-type containing 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zdhhc8provided by FlyBase
    Official Full Name
    Zinc finger DHHC-type containing 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0085478
    Locus tag
    Dmel_CG34449
    See related
    AllianceGenome:FB:FBgn0085478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-Pen16; CG12136; CG15372; CG17251; CG32705; CG34449; Dmel\CG34449; Dm_X:47283; dZDHHC8; p16; pen16; Pen16
    Old locus tag
    CG32705; Dmel_CG32705
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Is expressed in adult head and larval central nervous system. Orthologous to human ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5) and ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zdhhc8 in Genome Data Viewer
    Location:
    8D7-8D9; 1-27 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9324508..9356227, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9218541..9250260, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene c12.1 Neighboring gene c12.2 Neighboring gene uncharacterized protein Neighboring gene BCL7-like Neighboring gene Megalin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. pen repeat sequences are GGN clusters and encode a glycine-rich domain in a Drosophila cDNA homologous to the rat helix destabilizing protein. Haynes SR, et al. Proc Natl Acad Sci U S A, 1987 Apr. PMID 3031652, Free PMC Article
    2. Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability. Strassburger K, et al. PLoS One, 2019. PMID 30735487, Free PMC Article
    3. Evolutionary dynamics of U12-type spliceosomal introns. Lin CF, et al. BMC Evol Biol, 2010 Feb 17. PMID 20163699, Free PMC Article
    4. Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense. Deng Z, et al. J Genet Genomics, 2023 Dec. PMID 37343788
    5. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Praveen K, et al. Cell Rep, 2012 Jun 28. PMID 22813737, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger DHHC-type containing 8
    Names
    CG34449-PA
    CG34449-PB
    CG34449-PC
    CG34449-PD
    CG34449-PE
    CG34449-PF
    CG34449-PG
    Zdhhc8-PA
    Zdhhc8-PB
    Zdhhc8-PC
    Zdhhc8-PD
    Zdhhc8-PE
    Zdhhc8-PF
    Zdhhc8-PG
    NP_001096921.1
    NP_001096922.1
    NP_001245592.1
    NP_001259382.1
    NP_001285051.1
    NP_001285052.1
    NP_727339.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9324508..9356227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167189.6 → NP_727339.3  zinc finger DHHC-type containing 8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727339.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUM2, A8JUM5, M9NGX0, Q9W345, X2JE99, X2JJ56
      Conserved Domains (1) summary
      pfam01529
      Location:99 → 219
      DHHC; DHHC palmitoyltransferase

    2. NM_001298123.1 → NP_001285052.1  zinc finger DHHC-type containing 8, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JE99
      Conserved Domains (1) summary
      pfam01529
      Location:89 → 214
      zf-DHHC; DHHC palmitoyltransferase

    3. NM_001258663.3 → NP_001245592.1  zinc finger DHHC-type containing 8, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245592.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NGX0
      Conserved Domains (1) summary
      pfam01529
      Location:94 → 219
      zf-DHHC; DHHC palmitoyltransferase

    4. NM_001298122.1 → NP_001285051.1  zinc finger DHHC-type containing 8, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JJ56
      Conserved Domains (1) summary
      pfam01529
      Location:94 → 219
      zf-DHHC; DHHC palmitoyltransferase

    5. NM_001272453.1 → NP_001259382.1  zinc finger DHHC-type containing 8, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH36
      Conserved Domains (1) summary
      pfam01529
      Location:94 → 219
      zf-DHHC; DHHC palmitoyltransferase

    6. NM_001103451.3 → NP_001096921.1  zinc finger DHHC-type containing 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUM2
      Conserved Domains (1) summary
      pfam01529
      Location:94 → 219
      zf-DHHC; DHHC palmitoyltransferase

    7. NM_001103452.4 → NP_001096922.1  zinc finger DHHC-type containing 8, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096922.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUM5
      Conserved Domains (1) summary
      pfam01529
      Location:94 → 219
      zf-DHHC; DHHC palmitoyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PH36 M9PH36
    Q9W345.4 Q9W345

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