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    Lint-O L(3)mbt interactor in ovarian somatic cells [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31254, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lint-Oprovided by FlyBase
    Official Full Name
    L(3)mbt interactor in ovarian somatic cellsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024993
    Locus tag
    Dmel_CG2662
    See related
    AllianceGenome:FB:FBgn0024993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2662; Dmel\CG2662; EG:100G10.6; MAD; snuts
    Summary
    Enables chromatin binding activity. Involved in regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Is active in nucleus. Is expressed in several structures, including antennal primordium; anterior endoderm; embryonic/larval midgut primordium; head epidermis primordium; and mesoderm. Orthologous to human SAMD1 (sterile alpha motif domain containing 1) and SAMD13 (sterile alpha motif domain containing 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lint-O in Genome Data Viewer
    Location:
    3B2-3B2; 1-1.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2698701..2701033)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2592734..2595066)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene period Neighboring gene daywake Neighboring gene Paraplegin Neighboring gene UDP-galactose transporter Neighboring gene eukaryotic translation initiation factor 2B subunit beta Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression. Peterson AJ, et al. Genetics, 2004 Jul. PMID 15280237, Free PMC Article
    2. Lint-O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brain. Yamamoto-Matsuda H, et al. EMBO Rep, 2022 Oct 6. PMID 35993198, Free PMC Article
    3. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Reddy BA, et al. Mol Cell Biol, 2010 Nov. PMID 20733004, Free PMC Article
    4. LTR-mediated retroposition as a mechanism of RNA-based duplication in metazoans. Tan S, et al. Genome Res, 2016 Dec. PMID 27934698, Free PMC Article
    5. Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster. Schrider DR, et al. Genome Res, 2011 Dec. PMID 22135405, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L(3)mbt interactor in ovarian somatic cells
    Names
    CG2662-PA
    CG2662-PB
    L(3)mbt interactor in OSCs
    Lint-O-PA
    Lint-O-PB
    shrunken nuts

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2698701..2701033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297903.1 → NP_001284832.1  L(3)mbt interactor in ovarian somatic cells, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284832.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76866, Q9W4W7
      Conserved Domains (3) summary
      cd09583
      Location:371 → 438
      SAM_Atherin-like; SAM domain of Atherin/Atherin-like subfamily
      smart00454
      Location:371 → 436
      SAM; Sterile alpha motif
      smart00249
      Location:189 → 236
      PHD; PHD zinc finger

    2. NM_130662.3 → NP_570018.1  L(3)mbt interactor in ovarian somatic cells, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76866, Q9W4W7
      Related
      FBpp0070456
      Conserved Domains (3) summary
      cd09583
      Location:371 → 438
      SAM_Atherin-like; SAM domain of Atherin/Atherin-like subfamily
      smart00454
      Location:371 → 436
      SAM; Sterile alpha motif
      smart00249
      Location:189 → 236
      PHD; PHD zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76866 O76866
    Q9W4W7 Q9W4W7

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