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    Phf7 PHD finger protein 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33015, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phf7provided by FlyBase
    Official Full Name
    PHD finger protein 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0031091
    Locus tag
    Dmel_CG9576
    See related
    AllianceGenome:FB:FBgn0031091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9576; Dmel\CG9576; dPhf7; phf7; PHF7
    Summary
    Enables histone binding activity. Involved in male germ-line cyst formation; male germ-line sex determination; and positive regulation of gene expression. Located in male germ cell nucleus and polytene chromosome. Is expressed in several structures, including cuboidal/columnar epithelium; gonad; male germline cell; and male germline cyst. Orthologous to human PHF7 (PHD finger protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Phf7 in Genome Data Viewer
    Location:
    19B3-19C1; 1-64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20160355..20165830, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20054388..20059863, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene asperous Neighboring gene Rab35 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Annexin B10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis. Wang XR, et al. Proc Biol Sci, 2017 May 31. PMID 28539513, Free PMC Article
    2. Genetic control of a sex-specific piRNA program. Chen P, et al. Curr Biol, 2023 May 8. PMID 37059098, Free PMC Article
    3. Control of a Novel Spermatocyte-Promoting Factor by the Male Germline Sex Determination Factor PHF7 of Drosophila melanogaster. Yang SY, et al. Genetics, 2017 Aug. PMID 28588035, Free PMC Article
    4. Maternal Piwi regulates primordial germ cell development to ensure the fertility of female progeny in Drosophila. Gonzalez LE, et al. Genetics, 2021 Aug 26. PMID 34142134, Free PMC Article
    5. An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline. Smolko AE, et al. Development, 2020 Sep 11. PMID 32816970, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Safeguarding Drosophila female germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein.
      Title: Safeguarding Drosophila female germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein.
    2. Germline masculinization by Phf7 in D. melanogaster requires its evolutionarily novel C-terminus and the HP1-family protein HP1D3csd.
      Title: Germline masculinization by Phf7 in D. melanogaster requires its evolutionarily novel C-terminus and the HP1-family protein HP1D3csd.
    3. An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline.
      Title: An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline.
    4. Phf7 depletion reduces sex-dependent differences in gene expression and suppresses the enhanced malignant traits of male tumors.
      Title: The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila.
    5. PHF7 controls spermatogenesis by regulating the expression patterns of important male germline genes, including PEEPL1.
      Title: Control of a Novel Spermatocyte-Promoting Factor by the Male Germline Sex Determination Factor PHF7 of Drosophila melanogaster.
    6. Finger Protein 7 (PHF7) is an important factor for male germline sexual identity in Drosophila. Expression of PHF7 7 promotes spermatogenesis in XX germ cells when they are present in a male soma.
      Title: Phf7 controls male sex determination in the Drosophila germline.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in male germ-line cyst formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line sex determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in male germ-line sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PHD finger protein 7
    Names
    CG9576-PA
    CG9576-PB
    CG9576-PC
    PHD finger protein 7 ortholog
    Phf7-PA
    Phf7-PB
    Phf7-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20160355..20165830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272812.1 → NP_001259741.1  PHD finger protein 7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259741.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960N0, Q9W5W9
      Conserved Domains (1) summary
      cd15669
      Location:5 → 116
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

    2. NM_134530.3 → NP_608374.1  PHD finger protein 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608374.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960N0, Q9W5W9
      Related
      FBpp0070026
      Conserved Domains (1) summary
      cd15669
      Location:5 → 116
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

    3. NM_001272811.1 → NP_001259740.1  PHD finger protein 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259740.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960N0, Q9W5W9
      Conserved Domains (1) summary
      cd15669
      Location:5 → 116
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W5W9 Q9W5W9

    Gene LinkOut

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