dar1 dendritic arbor reduction 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dar1provided by FlyBase
Official Full Name: dendritic arbor reduction 1provided by FlyBase
Primary source: FLYBASE:FBgn0263239
Locus tag: Dmel_CG12029
See related: AllianceGenome:FB:FBgn0263239
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12029; Dar1; Dmel\CG12029; l(3)63Ed; l(3)SH5
Summary: Enables sequence-specific DNA binding activity. Involved in negative regulation of microtubule depolymerization; regulation of cell morphogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including abdominal dorsal multidendritic neurons; dorsal ridge; dorsal ridge primordium; embryonic epipharynx; and embryonic small intestine. Orthologous to human KLF5 (KLF transcription factor 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (3626352..3653442)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (3626352..3653442)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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