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    CG32191 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG32191provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052191
    Locus tag
    Dmel_CG32191
    See related
    AllianceGenome:FB:FBgn0052191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5584; Dmel\CG32191
    Summary
    Predicted to enable sulfuric ester hydrolase activity. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B); ARSI (arylsulfatase family member I); and ARSJ (arylsulfatase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG32191 in Genome Data Viewer
    Location:
    75A2-75A2; 3-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17806451..17809146, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17799551..17802246, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene aramis Neighboring gene uncharacterized protein Neighboring gene Cln3 Neighboring gene Ionotropic receptor 75a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. There are two distinct arylsulfatase activities in Drosophila. Pelliccia JG, et al. Biochem Genet, 1987 Aug. PMID 3447585
    2. Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Jansen IE, et al. Genome Biol, 2017 Jan 30. PMID 28137300, Free PMC Article
    3. Exploiting the Potential of Drosophila Models in Lysosomal Storage Disorders: Pathological Mechanisms and Drug Discovery. Rigon L, et al. Biomedicines, 2021 Mar 7. PMID 33800050, Free PMC Article
    4. A comprehensive study of genic variation in natural populations of Drosophila melanogaster. VI. Patterns and processes of genic divergence between D. melanogaster and its sibling species, Drosophila simulans. Choudhary M, et al. Genetics, 1992 Apr. PMID 1582561, Free PMC Article
    5. Patterns of gene expression during Drosophila mesoderm development. Furlong EE, et al. Science, 2001 Aug 31. PMID 11486054

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfuric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32191-PB
    CG32191-PC
    NP_001287102.1
    NP_730304.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17806451..17809146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300173.1 → NP_001287102.1  uncharacterized protein Dmel_CG32191, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287102.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KKB6, Q8IQS4
      Conserved Domains (3) summary
      COG3119
      Location:23 → 458
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16029
      Location:27 → 408
      4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B
      cl20644
      Location:478 → 540
      DUF4976; Domain of unknown function (DUF4976)

    2. NM_168750.4 → NP_730304.2  uncharacterized protein Dmel_CG32191, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730304.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KKB6, Q8IQS4
      Conserved Domains (3) summary
      COG3119
      Location:23 → 458
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16029
      Location:27 → 408
      4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B
      cl20644
      Location:478 → 540
      DUF4976; Domain of unknown function (DUF4976)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQS4 Q8IQS4

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