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    mip130 Myb-interacting protein 130 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mip130provided by FlyBase
    Official Full Name
    Myb-interacting protein 130provided by FlyBase
    Primary source
    FLYBASE:FBgn0023509
    Locus tag
    Dmel_CG3480
    See related
    AllianceGenome:FB:FBgn0023509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    86E4.4; CG3480; Dmel\CG3480; EG:86E4.4; Mip130; Mip130/TWIT; Mip130/Twt; twit; Twit; TWIT
    Summary
    Enables DNA binding activity. Involved in centrosome cycle and negative regulation of transcription by RNA polymerase II. Located in chromatin. Part of DRM complex and Myb complex. Is active in nucleus. Is expressed in adult brain cell body rind; adult head; and organism. Orthologous to human LIN9 (lin-9 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mip130 in Genome Data Viewer
    Location:
    2B15-2B16; 1-0.2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1908239..1920318)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1802272..1814351)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45929 Neighboring gene antisense RNA:CR43864 Neighboring gene Lipid droplet assembly factor 1 Neighboring gene uncharacterized protein Neighboring gene ER degradation enhancer, mannosidase alpha-like 1 Neighboring gene Rabconnectin-3B Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon Neighboring gene Oculocerebrorenal syndrome of Lowe Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. Beall EL, et al. Genes Dev, 2004 Jul 15. PMID 15256498, Free PMC Article
    2. The dREAM/Myb-MuvB complex and Grim are key regulators of the programmed death of neural precursor cells at the Drosophila posterior wing margin. Rovani MK, et al. Dev Biol, 2012 Dec 1. PMID 22960039, Free PMC Article
    3. A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes. Vorster PJ, et al. Biol Open, 2020 May 7. PMID 32295830, Free PMC Article
    4. Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex. Andrejka L, et al. Proc Natl Acad Sci U S A, 2011 Oct 18. PMID 21969598, Free PMC Article
    5. Epigenetic regulation of olfactory receptor gene expression by the Myb-MuvB/dREAM complex. Sim CK, et al. Genes Dev, 2012 Nov 15. PMID 23105004, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that L(3)mbt chromosomal targeting requires proteins of a site-specific DNA binding complex Myb-MuvB (MMB core component Mip130)/DREAM.
      Title: Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment.
    2. Cell cycle specific degradation of Mip130 is likely to be utilized as a key regulatory mechanism in down-regulating the activity of the Myb complex.
      Title: Two components of the Myb complex, DMyb and Mip130, are specifically associated with euchromatin and degraded during prometaphase throughout development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eggshell chorion gene amplification IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DRM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Myb complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription repressor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Myb-interacting protein 130
    Names
    CG3480-PA
    mip130-PA
    twilight

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1908239..1920318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130602.4 → NP_569958.2  Myb-interacting protein 130 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569958.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46093, Q9W542
      Related
      FBpp0070302
      Conserved Domains (1) summary
      pfam06584
      Location:311 → 419
      DIRP; DIRP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46093 O46093
    Q9W542 Q9W542

    Gene LinkOut

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