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    Tmx3 Thioredoxin-related transmembrane protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmx3provided by FlyBase
    Official Full Name
    Thioredoxin-related transmembrane protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0036579
    Locus tag
    Dmel_CG5027
    See related
    AllianceGenome:FB:FBgn0036579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5027; Dmel\CG5027; DmTMX3; LD24073p
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including CNS glial cell; adult head; central brain primordium; ganglia; and photoreceptor. Orthologous to human TMX3 (thioredoxin related transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmx3 in Genome Data Viewer
    Location:
    72D10-72D10; 3-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16229100..16231139)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16222200..16224239)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Methionine-CAT 1-3 Neighboring gene lethal (3) 72Dn Neighboring gene Programmed Cell Death 5 Neighboring gene Mediator complex subunit 10 Neighboring gene Heat shock protein cognate 20 Neighboring gene lethal (3) 72Dp

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions. Ihara M, et al. Proc Natl Acad Sci U S A, 2020 Jul 14. PMID 32611810, Free PMC Article
    2. The thioredoxin-like fold: hidden domains in protein disulfide isomerases and other chaperone proteins. Clissold PM, et al. Bioessays, 2003 Jun. PMID 12766950
    3. Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors-targets of neonicotinoids. Komori Y, et al. PLoS Genet, 2023 Feb. PMID 36795653, Free PMC Article
    4. Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code. Xie Q, et al. Neuron, 2022 Jul 20. PMID 35613619, Free PMC Article
    5. Testing candidate genes for attention-deficit/hyperactivity disorder in fruit flies using a high throughput assay for complex behavior. Rohde PD, et al. Fly (Austin), 2016 Jan 2. PMID 26954609, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Thioredoxin-related transmembrane protein 3
    Names
    CG5027-PA
    Tmx3-PA
    NP_648847.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16229100..16231139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140590.4 → NP_648847.3  Thioredoxin-related transmembrane protein 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648847.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961B9, Q9VUZ7
      Related
      FBpp0075212
      Conserved Domains (2) summary
      cd03000
      Location:27 → 128
      PDI_a_TMX3; PDIa family, TMX3 subfamily; composed of eukaryotic proteins similar to human TMX3, a TRX related transmembrane protein containing one redox active TRX domain at the N-terminus and a classical ER retrieval sequence for type I transmembrane proteins at ...
      TIGR01130
      Location:28 → 355
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961B9 Q961B9

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