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    unpg unplugged [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35942, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unpgprovided by FlyBase
    Official Full Name
    unpluggedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015561
    Locus tag
    Dmel_CG1650
    See related
    AllianceGenome:FB:FBgn0015561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1912; anon-45C; CG1650; Dmel\CG1650; Gbx; unp; upg
    Summary
    Enables DNA-binding transcription factor activity. Involved in brain development; regulation of DNA-templated transcription; and regulation of nervous system development. Located in nucleus. Is expressed in several structures, including neuroblasts; neurogenic region; neuromere; primary tracheal branch; and tracheal pit. Orthologous to human GBX1 (gastrulation brain homeobox 1) and GBX2 (gastrulation brain homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See unpg in Genome Data Viewer
    Location:
    45B3-45B3; 2-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9195205..9199870)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5082710..5087375)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rab32 Neighboring gene long non-coding RNA:CR44284 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene N-acetylglucosamine-1-phosphate transferase subunits alpha and beta Neighboring gene Vacuolar H[+] ATPase AC45 accessory subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting. Li H, et al. Curr Biol, 2020 Apr 6. PMID 32059767, Free PMC Article
    2. An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila. Hirth F, et al. Development, 2003 Jun. PMID 12702651
    3. Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax complex. Chiang C, et al. Development, 1995 Nov. PMID 8582298
    4. Gene expression mapping of the neuroectoderm across phyla - conservation and divergence of early brain anlagen between insects and vertebrates. Posnien N, et al. Elife, 2023 Sep 26. PMID 37750868, Free PMC Article
    5. The role of the cell cycle and cytokinesis in regulating neuroblast sublineage gene expression in the Drosophila CNS. Cui X, et al. Development, 1995 Oct. PMID 7588058

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting.
      Title: Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting.
    2. Mutational inactivation of otd/Otx2 and unpg/Gbx2 result in the loss or misplacement of the brain-specific expression domains of Pax2/5/8 and Hox genes.
      Title: An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    unplugged
    Names
    CG1650-PA
    unpg-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9195205..9199870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057798.3 → NP_477146.1  unplugged [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477146.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24136, Q4V5A3
      Related
      FBpp0087667
      Conserved Domains (1) summary
      pfam00046
      Location:324 → 375
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V5A3.1 Q4V5A3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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