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    Csas CMP-sialic acid synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Csasprovided by FlyBase
    Official Full Name
    CMP-sialic acid synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052220
    Locus tag
    Dmel_CG32220
    See related
    AllianceGenome:FB:FBgn0052220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32220; CSAS; DmCSAS; Dmel\CG32220
    Summary
    Enables N-acylneuraminate cytidylyltransferase activity. Involved in CMP-N-acetylneuraminate biosynthetic process; chemical synaptic transmission; and response to heat. Located in trans-Golgi network. Is expressed in adult brain; adult head; embryonic/larval crystal cell; and larval central nervous system. Orthologous to human CMAS (cytidine monophosphate N-acetylneuraminic acid synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Csas in Genome Data Viewer
    Location:
    76D8-76D8; 3-46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19988027..19988991, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19981127..19982047, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hale-bopp Neighboring gene schumacher-levy Neighboring gene antisense RNA:CR45161 Neighboring gene flightin Neighboring gene uncharacterized protein Neighboring gene Neurocalcin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Drosophila CMP-sialic acid synthetase activity reveals unusual enzymatic properties. Mertsalov IB, et al. Biochem J, 2016 Jul 1. PMID 27114558, Free PMC Article
    2. Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase. Differential localization of the Drosophila and human enzymes. Viswanathan K, et al. J Biol Chem, 2006 Jun 9. PMID 16537535
    3. Sialylation and sialyltransferase in insects. Ghosh S. Glycoconj J, 2018 Oct. PMID 30058043
    4. Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila. Scott H, et al. Elife, 2023 Mar 22. PMID 36946697, Free PMC Article
    5. The role of Drosophila cytidine monophosphate-sialic acid synthetase in the nervous system. Islam R, et al. J Neurosci, 2013 Jul 24. PMID 23884937, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acylneuraminate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acylneuraminate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acylneuraminate cytidylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CMP-N-acetylneuraminate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CMP-sialic acid synthase
    Names
    CG32220-PB
    CMP-Sialic acid synthetase
    Csas-PB
    cytidine monophosphate-sialic acid synthetase
    NP_730474.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19988027..19988991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168828.3 → NP_730474.2  CMP-sialic acid synthase [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJF3, Q8IQV0
      Conserved Domains (1) summary
      cd02513
      Location:32 → 240
      CMP-NeuAc_Synthase; CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQV0 Q8IQV0

    Gene LinkOut

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