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    Polr2J RNA polymerase II subunit J [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr2Jprovided by FlyBase
    Official Full Name
    RNA polymerase II subunit Jprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032634
    Locus tag
    Dmel_CG6840
    See related
    AllianceGenome:FB:FBgn0032634
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM15177; CG6840; Dmel\CG6840; Rpb11; RPB11
    Summary
    Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to RNA polymerase II activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be part of RNA polymerase II, core complex. Orthologous to human POLR2J (RNA polymerase II subunit J); POLR2J2 (RNA polymerase II subunit J2); and POLR2J3 (RNA polymerase II subunit J3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr2J in Genome Data Viewer
    Location:
    36C7-36C7; 2-53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17409698..17410406, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17409698..17410406, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Leucine-rich-repeats and calponin homology domain protein Neighboring gene Cytoplasmic linker protein 190 Neighboring gene uncharacterized protein Neighboring gene Radial spoke head protein 9 Neighboring gene Dorsal-related immunity factor Neighboring gene long non-coding RNA:CR44409

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system. Beaven R, et al. Mol Biol Cell, 2015 Apr 15. PMID 25694447, Free PMC Article
    2. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
    3. Close head-to-head juxtaposition of genes favors their coordinate regulation in Drosophila melanogaster. Herr DR, et al. FEBS Lett, 2004 Aug 13. PMID 15304339
    4. Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation. Aoyagi N, et al. J Cell Biol, 2000 Jul 24. PMID 10908585, Free PMC Article
    5. Identification of regulators of the three-dimensional polycomb organization by a microscopy-based genome-wide RNAi screen. Gonzalez I, et al. Mol Cell, 2014 May 8. PMID 24703951

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA-directed 5'-3' RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase II activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA polymerase II subunit J
    Names
    CG6840-PA
    Polr2J-PA
    Rpb11

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17409698..17410406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135992.4 → NP_609836.1  RNA polymerase II subunit J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609836.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJE4
      UniProtKB/TrEMBL
      G2J5V6, G2J5W1
      Related
      FBpp0080564
      Conserved Domains (1) summary
      cd06926
      Location:14 → 105
      RNAP_II_RPB11; RPB11 subunit of Eukaryotic RNA polymerase II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IH32 Q8IH32
    Q9VJE4.1 Q9VJE4

    Gene LinkOut

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