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    Snap25 Synaptosomal-associated protein 25kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355084, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snap25provided by FlyBase
    Official Full Name
    Synaptosomal-associated protein 25kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011288
    Locus tag
    Dmel_CG40452
    See related
    AllianceGenome:FB:FBgn0011288
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17676; CG17884; CG40452; Dmel\CG40452; dSNAP-25; dSnap25; snap-25; SNAP-25; snap25; SNAP25; snp25
    Summary
    Enables SNAP receptor activity and SNARE binding activity. Involved in chemical synaptic transmission; regulation of short-term neuronal synaptic plasticity; and synaptic vesicle transport. Located in terminal bouton. Part of SNARE complex. Is expressed in several structures, including abdominal neuromere; adult brain; adult head; adult optic lobe; and ganglia. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to several human genes including SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Snap25 in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (24074180..24299205)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (24067280..24292305)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR40053 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45159 Neighboring gene neverland Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation of synaptosome-associated protein 25 kDa (SNAP-25) shown by Drosophila and Torpedo cDNA clones. Risinger C, et al. J Biol Chem, 1993 Nov 15. PMID 8226991
    2. Complex gene organization of synaptic protein SNAP-25 in Drosophila melanogaster. Risinger C, et al. Gene, 1997 Jul 31. PMID 9272858
    3. Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis. Washbourne P, et al. FEBS Lett, 1997 Nov 24. PMID 9414082
    4. Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant. Rao SS, et al. EMBO J, 2001 Dec 3. PMID 11726512, Free PMC Article
    5. Arg206 of SNAP-25 is essential for neuroexocytosis at the Drosophila melanogaster neuromuscular junction. Megighian A, et al. J Cell Sci, 2010 Oct 1. PMID 20826463

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results indicate that SNAP-25-R206 and syntaxin-D253 play a major role in neuroexocytosis and support a radial assembly of several SNARE complexes interacting via the ionic couple formed by these two residues.
      Title: Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction.
    2. Results establish in vivo contributions of SNAP-25 and NSF to synaptic vesicle trafficking and define molecular mechanisms determining conserved functional properties of short-term depression.
      Title: Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants.
    3. study found dHIP14 to be an essential maternal effect gene required for photoreceptor synaptic transmission and for proper in vivo expression of the palmitoylated presynaptic proteins SNAP-25 and cysteine string protein
      Title: Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein.
    4. reveals context-dependent redundancy with SNAP-24 in neurotransmission
      Title: A Drosophila SNAP-25 null mutant reveals context-dependent redundancy with SNAP-24 in neurotransmission.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 24272148-24279757 mobile_element_type = transposon:opus{}6618
    • Loc: 24280512-24281594 mobile_element_type = transposon:1360{}6361
    • Loc: 24292035-24293047 mobile_element_type = transposon:1360{}6363

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuromuscular synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of short-term neuronal synaptic plasticity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle docking NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Synaptosomal-associated protein 25kDa
    Names
    CG40452-PA
    CG40452-PC
    Snap25-PA
    Snap25-PC
    synapse protein 25
    synaptosomal-associated protein 25

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      24074180..24299205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043176.2 → NP_001036641.1  Synaptosomal-associated protein 25kDa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036641.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F3YD56, P36975, Q5LJU6, Q7PLV2
      Conserved Domains (3) summary
      cd15885
      Location:151 → 209
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15889
      Location:28 → 87
      SNARE_SNAP25N_23N; N-terminal SNARE motif of SNAP25 and SNAP23
      pfam00835
      Location:98 → 149
      SNAP-25; SNAP-25 family

    2. NM_001043177.3 → NP_001036642.2  Synaptosomal-associated protein 25kDa, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036642.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36975
      Conserved Domains (3) summary
      cd15885
      Location:151 → 209
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15889
      Location:28 → 87
      SNARE_SNAP25N_23N; N-terminal SNARE motif of SNAP25 and SNAP23
      pfam00835
      Location:98 → 149
      SNAP-25; SNAP-25 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36975.1 P36975

    Gene LinkOut

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