qkr58E-3 quaking related 58E-3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: qkr58E-3provided by FlyBase
Official Full Name: quaking related 58E-3provided by FlyBase
Primary source: FLYBASE:FBgn0022984
Locus tag: Dmel_CG3584
See related: AllianceGenome:FB:FBgn0022984
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3584; Dmel\CG3584; kep1; KEP1; qkr58e-3; QKR58E-3; qrk58E-3
Summary: Enables RNA binding activity. Involved in apoptotic process and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in follicle cell; nurse cell; and organism. Orthologous to human KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 58D7-58D8; 2-99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22409208..22411545, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18296713..18299050, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

interacts genetically with dredd/caspase-8, and kep1 mutants alter the balance of dredd isoforms
Title: Kep1 interacts genetically with dredd/caspase-8, and kep1 mutants alter the balance of dredd isoforms.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISM Inferred from Sequence Model more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: quaking related 58E-3

Names: CG3584-PB; CG3584-PC; CG3584-PD; KH domain encompassing protein 1; qkr58E-3-PB; qkr58E-3-PC; qkr58E-3-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22409208..22411545 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299792.1 → NP_001286721.1 quaking related 58E-3, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286721.1

Status: REVIEWED

UniProtKB/TrEMBL

O44434, Q9TZN6

Conserved Domains (1) summary

cd02395
Location:81 → 200

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
NM_001259531.2 → NP_001246460.1 quaking related 58E-3, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246460.1

Status: REVIEWED

UniProtKB/TrEMBL

O44434, Q9TZN6

Conserved Domains (1) summary

cd02395
Location:81 → 200

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
NM_057958.5 → NP_477306.3 quaking related 58E-3, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477306.3

Status: REVIEWED

UniProtKB/TrEMBL

O44434, Q9TZN6

Conserved Domains (1) summary

cd02395
Location:81 → 200

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...