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    CG10365 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10365provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039109
    Locus tag
    Dmel_CG10365
    See related
    AllianceGenome:FB:FBgn0039109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.386; Chac1; Dmel\CG10365
    Summary
    Predicted to enable Notch binding activity and glutathione specific gamma-glutamylcyclotransferase activity. Predicted to be involved in glutathione catabolic process and neurogenesis. Predicted to be located in trans-Golgi network. Predicted to be active in cytoplasm. Is expressed in several structures, including amnioserosa; anterior endoderm; anterior endoderm anlage; embryonic/larval salivary gland; and posterior ectoderm anlage. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10365 in Genome Data Viewer
    Location:
    95B1-95B1; 3-80 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23723331..23731499)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19549053..19557221)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nautilus Neighboring gene uncharacterized protein Neighboring gene Ribonuclease MRP RNA Neighboring gene Regulatory particle non-ATPase 9 Neighboring gene HMG Coenzyme A reductase Neighboring gene antisense RNA:CR46091 Neighboring gene Ran binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of the Drosophila MRP (mitochondrial RNA processing) RNA gene. Schneider MD, et al. RNA, 2010 Nov. PMID 20855541, Free PMC Article
    2. In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila. Wong SL, et al. Biochem Biophys Res Commun, 2005 Nov 18. PMID 16212942, Free PMC Article
    3. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
    4. Parallel and population-specific gene regulatory evolution in cold-adapted fly populations. Huang Y, et al. Genetics, 2021 Jul 14. PMID 33989401, Free PMC Article
    5. Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway. Dialynas G, et al. PLoS Genet, 2015 May. PMID 25996830, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Notch binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10365-PA
    CG10365-PB
    CG10365-PC
    CG10365-PD
    NP_651176.1
    NP_732896.1
    NP_732897.1
    NP_996270.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23723331..23731499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170087.2 → NP_732897.1  uncharacterized protein Dmel_CG10365, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCI9
      Related
      FBpp0083838
      Conserved Domains (1) summary
      pfam04752
      Location:57 → 224
      ChaC; ChaC-like protein

    2. NM_206547.2 → NP_996270.1  uncharacterized protein Dmel_CG10365, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996270.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCI9
      Conserved Domains (1) summary
      pfam04752
      Location:57 → 224
      ChaC; ChaC-like protein

    3. NM_170086.2 → NP_732896.1  uncharacterized protein Dmel_CG10365, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCI9
      Related
      FBpp0083839
      Conserved Domains (1) summary
      pfam04752
      Location:57 → 224
      ChaC; ChaC-like protein

    4. NM_142919.2 → NP_651176.1  uncharacterized protein Dmel_CG10365, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCI9
      Related
      FBpp0083840
      Conserved Domains (1) summary
      pfam04752
      Location:57 → 224
      ChaC; ChaC-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCI9 Q9VCI9

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