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    CG6565 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6565provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032513
    Locus tag
    Dmel_CG6565
    See related
    AllianceGenome:FB:FBgn0032513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6565
    Summary
    Predicted to enable lipid binding activity. Involved in inner mitochondrial membrane organization. Is active in mitochondrial membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 2. Orthologous to human STARD7 (StAR related lipid transfer domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6565 in Genome Data Viewer
    Location:
    34B8-34B8; 2-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13374019..13376404)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13374019..13376404)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B22 subunit Neighboring gene B double prime 1 Neighboring gene uncharacterized protein Neighboring gene Coat Protein (coatomer) beta'

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis. Ables ET, et al. G3 (Bethesda), 2016 Aug 9. PMID 27226164, Free PMC Article
    2. Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity. Murari A, et al. Cell Rep, 2023 Aug 29. PMID 37516961, Free PMC Article
    3. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Kim YW, et al. Alzheimers Dement, 2021 May. PMID 33576571, Free PMC Article
    4. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189
    5. Dynamics of Dark-Fly Genome Under Environmental Selections. Izutsu M, et al. G3 (Bethesda), 2015 Dec 4. PMID 26637434, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine transfer activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inner mitochondrial membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6565-PA
    CG6565-PB
    CG6565-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13374019..13376404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298962.1 → NP_001285891.1  uncharacterized protein Dmel_CG6565, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJZ2
      Conserved Domains (1) summary
      cd08911
      Location:170 → 377
      START_STARD7-like; Lipid-binding START domain of mammalian STARD7 and related proteins

    2. NM_001298963.1 → NP_001285892.1  uncharacterized protein Dmel_CG6565, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJZ2
      Conserved Domains (1) summary
      cd08911
      Location:170 → 377
      START_STARD7-like; Lipid-binding START domain of mammalian STARD7 and related proteins

    3. NM_135800.3 → NP_609644.1  uncharacterized protein Dmel_CG6565, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609644.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJZ2
      Related
      FBpp0080047
      Conserved Domains (1) summary
      cd08911
      Location:170 → 377
      START_STARD7-like; Lipid-binding START domain of mammalian STARD7 and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJZ2 Q9VJZ2

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