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    Phb2 Prohibitin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46038, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phb2provided by FlyBase
    Official Full Name
    Prohibitin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0010551
    Locus tag
    Dmel_CG15081
    See related
    AllianceGenome:FB:FBgn0010551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.157; anon-WO02079478.4; CG15081; Dmel\CG15081; l (2) 03709; l(2)03709; l(2)3709; phb2
    Summary
    Predicted to be involved in mitochondrion organization. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; embryonic/larval midgut primordium; and epithelial cell. Orthologous to human PHB2 (prohibitin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Phb2 in Genome Data Viewer
    Location:
    55F5-55F6; 2-86 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18819467..18822250)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14706972..14709755)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43418 Neighboring gene long non-coding RNA:CR46234 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel ability of diflubenzuron as an inhibitor of mitochondrial function. Mori K, et al. Insect Biochem Mol Biol, 2024 Apr. PMID 38342197
    2. Aza-Flavanone Diminishes Parkinsonism in the Drosophila melanogasterParkin Mutant. Pant C, et al. ACS Chem Neurosci, 2021 Dec 1. PMID 34763419
    3. Comparative Ubiquitome Analysis Reveals Deubiquitinating Effects Induced by Wolbachia Infection in Drosophila melanogaster. Zong Q, et al. Int J Mol Sci, 2022 Aug 21. PMID 36012723, Free PMC Article
    4. Evolutionary dynamics of U12-type spliceosomal introns. Lin CF, et al. BMC Evol Biol, 2010 Feb 17. PMID 20163699, Free PMC Article
    5. Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population. Marriage TN, et al. Genetics, 2014 Sep. PMID 25236448, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial prohibitin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prohibitin 2
    Names
    CG15081-PA
    CG15081-PB
    CG15081-PC
    CG15081-PD
    CG15081-PE
    CG15081-PF
    Phb2-PA
    Phb2-PB
    Phb2-PC
    Phb2-PD
    Phb2-PE
    Phb2-PF
    lethal (2) 03709
    lethal(2)03709

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18819467..18822250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103902.1 → NP_001097372.1  prohibitin 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYI6
      Conserved Domains (1) summary
      cd03401
      Location:42 → 236
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. NM_001103903.2 → NP_001097373.1  prohibitin 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E924, Q9V8N2
      Conserved Domains (1) summary
      cd03401
      Location:42 → 236
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    3. NM_166311.3 → NP_725831.2  prohibitin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725831.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E924, Q9V8N2
      Conserved Domains (1) summary
      cd03401
      Location:42 → 236
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    4. NM_143773.4 → NP_652030.3  prohibitin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652030.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E924, Q9V8N2
      Conserved Domains (1) summary
      cd03401
      Location:42 → 236
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    5. NM_001103901.1 → NP_001097371.1  prohibitin 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYI7
      Conserved Domains (2) summary
      PRK11029
      Location:205 → 278
      PRK11029; protease modulator HflC
      cd03401
      Location:42 → 236
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    6. NM_166312.3 → NP_725832.2  prohibitin 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725832.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E924, Q9V8N2
      Conserved Domains (1) summary
      cd03401
      Location:42 → 236
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYI6 A8DYI6
    A8DYI7 A8DYI7
    Q0E924 Q0E924

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