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    Rpt3 Regulatory particle triple-A ATPase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32047, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpt3provided by FlyBase
    Official Full Name
    Regulatory particle triple-A ATPase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0028686
    Locus tag
    Dmel_CG16916
    See related
    AllianceGenome:FB:FBgn0028686
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    16916; CG16916; Dmel\CG16916; Dmp48A; Dm_Rpt3a; l(1)G0052; p48A; rpt3; S6; S6B; TBP7
    Summary
    Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in male germ cell nucleus. Part of proteasome regulatory particle, base subcomplex. Is expressed in adult head and organism. Used to study neurodegenerative disease. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpt3 in Genome Data Viewer
    Location:
    10A6-10A6; 1-33 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11125101..11126785)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11019134..11020818)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Heat shock protein 60A Neighboring gene uncharacterized protein Neighboring gene Signal recognition particle receptor alpha Neighboring gene Kinesin-like protein at 10A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster. Adám G, et al. Gene Expr Patterns, 2004 May. PMID 15053983
    2. A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1. Watson MR, et al. J Biol Chem, 2008 Sep 5. PMID 18596033, Free PMC Article
    3. Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit. Lipinszki Z, et al. FEBS J, 2011 Dec. PMID 21973017
    4. Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors. Lipinszki Z, et al. Biochemistry, 2012 Mar 27. PMID 22364263
    5. Evolution of proteasomal ATPases. Wollenberg K, et al. Mol Biol Evol, 2001 Jun. PMID 11371584

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome-activating activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulatory particle triple-A ATPase 3
    Names
    CG16916-PA
    CG16916-PB
    Rpt3-PA
    Rpt3-PB
    NP_001285108.1
    NP_572686.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11125101..11126785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298179.1 → NP_001285108.1  regulatory particle triple-A ATPase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1UIA5, Q9V405
      Conserved Domains (2) summary
      PTZ00454
      Location:22 → 413
      PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
      pfam00004
      Location:197 → 330
      AAA; ATPase family associated with various cellular activities (AAA)

    2. NM_132458.3 → NP_572686.1  regulatory particle triple-A ATPase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572686.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1UIA5, Q9V405
      Related
      FBpp0073292
      Conserved Domains (2) summary
      PTZ00454
      Location:22 → 413
      PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
      pfam00004
      Location:197 → 330
      AAA; ATPase family associated with various cellular activities (AAA)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V405 Q9V405

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