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    Spn88Eb Serpin 88Eb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41829, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn88Ebprovided by FlyBase
    Official Full Name
    Serpin 88Ebprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038299
    Locus tag
    Dmel_CG6687
    See related
    AllianceGenome:FB:FBgn0038299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6687; Dmel\CG6687; serpin; Spn88EB
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in epithelium regeneration and regulation of stem cell division. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); lung disease (multiple); retinal vascular disease (multiple); and thrombophilia (multiple). Orthologous to several human genes including SERPINC1 (serpin family C member 1); SERPINE2 (serpin family E member 2); and SERPINI2 (serpin family I member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn88Eb in Genome Data Viewer
    Location:
    88E3-88E3; 3-56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15206703..15208762, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11032425..11034484, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1 Neighboring gene uncharacterized protein Neighboring gene Serpin 88Ea Neighboring gene Mau2 sister chromatid cohesion factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Shal Interactor of Di-Leucine Motif

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The serpin Spn5 is essential for wing expansion in Drosophila melanogaster. Charron Y, et al. Int J Dev Biol, 2008. PMID 18956323
    2. A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade. Colinet D, et al. Dev Comp Immunol, 2009 May. PMID 19109990
    3. The neuropeptide Drosulfakinin regulates social isolation-induced aggression in Drosophila. Agrawal P, et al. J Exp Biol, 2020 Jan 29. PMID 31900346, Free PMC Article
    4. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    5. Peptidomic and proteomic analyses of the systemic immune response of Drosophila. Levy F, et al. Biochimie, 2004 Sep-Oct. PMID 15556270

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelium regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in regulation of stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to fungus HEP PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 88Eb
    Names
    CG6687-PA
    Dm-serpin-88Eb
    Spn88Eb-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15206703..15208762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142170.3 → NP_650427.1  serpin 88Eb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650427.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4VA01, Q9VFC1
      Related
      FBpp0082594
      Conserved Domains (1) summary
      cd00172
      Location:37 → 418
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFC1 Q9VFC1

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