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    CG5390 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5390provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032213
    Locus tag
    Dmel_CG5390
    See related
    AllianceGenome:FB:FBgn0032213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH06341; c-SPH35; cSPH35; Dmel\CG5390; gh06341; SPH; SPH35
    Summary
    Enables peptidase activator activity. Involved in melanization defense response and zymogen activation. Located in extracellular region. Is expressed in adult head; adult heart; amnioserosa; spermatozoon; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5390 in Genome Data Viewer
    Location:
    31D1-31D1; 2-41 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10304069..10306594, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10304069..10306594, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene no mitochondrial derivative Neighboring gene uncharacterized protein Neighboring gene Cdk5 activator-like protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ectopic expression of an endoparasitic wasp venom protein in Drosophila melanogaster affects immune function, larval development and oviposition. Thomas P, et al. Insect Mol Biol, 2010 Aug. PMID 20408903
    2. Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster. Jin Q, et al. Front Immunol, 2023. PMID 37781370, Free PMC Article
    3. Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Connell-Crowley L, et al. Mech Dev, 2007 May. PMID 17368005, Free PMC Article
    4. Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Xue L, et al. Dev Cell, 2007 Sep. PMID 17765686
    5. The instantly released Drosophila immune proteome is infection-specific. Vierstraete E, et al. Biochem Biophys Res Commun, 2004 May 14. PMID 15094375

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster.
      Title: Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zymogen activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5390-PA
    CG5390-PB
    serine protease homologue protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10304069..10306594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135530.3 → NP_609374.1  uncharacterized protein Dmel_CG5390, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609374.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PE8, Q9VL01
      Related
      FBpp0079653
      Conserved Domains (2) summary
      smart00020
      Location:153 → 390
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:153 → 391
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001298873.1 → NP_001285802.1  uncharacterized protein Dmel_CG5390, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PE8, Q9VL01
      Conserved Domains (2) summary
      smart00020
      Location:153 → 390
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:153 → 391
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86PE8 Q86PE8
    Q9VL01 Q9VL01

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