spz5 spatzle 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: spz5provided by FlyBase
Official Full Name: spatzle 5provided by FlyBase
Primary source: FLYBASE:FBgn0035379
Locus tag: Dmel_CG9972
See related: AllianceGenome:FB:FBgn0035379
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9972; CT28115; Dmel\CG9972; DNT2; NT2; spz-5; Spz-5; Spz5
Summary: Enables Toll binding activity and growth factor activity. Involved in several processes, including Toll signaling pathway; nervous system development; and regulation of neuronal synaptic plasticity in response to neurotrophin. Located in extracellular space. Is expressed in several structures, including adult fat body; embryonic epipharynx; embryonic hypopharynx; epithelium; and hypodermal muscle cell of A1-7. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (2883641..2892166, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (2883641..2892166, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables Toll binding	IBA Inferred from Biological aspect of Ancestor more info
enables Toll binding	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Toll signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in central nervous system formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuronal synaptic plasticity in response to neurotrophin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed