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    Gp93 Glycoprotein 93 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43354, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gp93provided by FlyBase
    Official Full Name
    Glycoprotein 93provided by FlyBase
    Primary source
    FLYBASE:FBgn0039562
    Locus tag
    Dmel_CG5520
    See related
    AllianceGenome:FB:FBgn0039562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5520; CT17486; dGRP94; dHSP90; Dmel\CG5520; gp93; GP93; Hsp90; HSP90; Hsp90aa1; HSP90B1; p93; Q9VAY2
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Involved in endodermal digestive tract morphogenesis and midgut development. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic proventriculus; embryonic ventral epidermis; and epithelium. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gp93 in Genome Data Viewer
    Location:
    98B6-98B6; 3-94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27948711..27952151)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23774433..23777873)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Biorientation Defective 1 Neighboring gene mitoferrin Neighboring gene uncharacterized protein Neighboring gene Neprilysin 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromatin Immunoprecipitation (ChIP) of Heat Shock Protein 90 (Hsp90). Sawarkar R. Methods Mol Biol, 2023. PMID 37540426
    2. Development of a Grp94 inhibitor. Duerfeldt AS, et al. J Am Chem Soc, 2012 Jun 13. PMID 22642269, Free PMC Article
    3. Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins. Morales C, et al. J Immunol, 2009 Oct 15. PMID 19786553, Free PMC Article
    4. Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages. Pantzartzi CN, et al. PLoS One, 2013. PMID 24066039, Free PMC Article
    5. Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms. Chen B, et al. BMC Genomics, 2006 Jun 17. PMID 16780600, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion.
      Title: Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion.
    2. Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization.
      Title: Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization.
    3. analysis of the role of Drosophila CNPYa and CNPYb in gp93 biology
      Title: Drosophila canopy b is a cochaperone of glycoprotein 93.
    4. an essential role for Gp93 in the functional expression of secretory/integral membrane protein-encoding lab protein target genes and/or integral membrane protein(s) that interact with the spectrin cytoskeleton to confer epithelial membrane specialization
      Title: Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control.
    5. gp93 is the Drosophila ortholog of gp96, the chaperone function of the two molecules is conserved.
      Title: Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endodermal digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in midgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of IRE1-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glycoprotein 93
    Names
    CG5520-PA
    Gp93-PA
    glycoprotein93
    heat shock protein 90

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27948711..27952151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143344.3 → NP_651601.1  glycoprotein 93 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAY2
      Related
      FBpp0084623
      Conserved Domains (3) summary
      PRK05218
      Location:74 → 745
      PRK05218; heat shock protein 90; Provisional
      cd00075
      Location:97 → 216
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      pfam00183
      Location:257 → 748
      HSP90; Hsp90 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAY2 Q9VAY2

    Gene LinkOut

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