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    unc-4 unc-4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-4provided by FlyBase
    Official Full Name
    unc-4provided by FlyBase
    Primary source
    FLYBASE:FBgn0024184
    Locus tag
    Dmel_CG6269
    See related
    AllianceGenome:FB:FBgn0024184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6269; Dmel\CG6269; DPHD-1; Dunc-4; Unc-4; Unc4
    Summary
    Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of gene expression. Is expressed in several structures, including genitalia; imaginal disc; motor neurons; segmentally-repeated neuroblast; and sensory neurons. Orthologous to human UNCX (UNC homeobox). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See unc-4 in Genome Data Viewer
    Location:
    16C10-16D1; 1-58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17768569..17778708)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17662602..17672741)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene raskol Neighboring gene Ods-site homeobox Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells. Tabuchi K, et al. Neurosci Lett, 1998 Nov 20. PMID 9857963
    2. A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus (OdsH). Nunes WVB, et al. G3 (Bethesda), 2024 Mar 6. PMID 38156703, Free PMC Article
    3. Sex and speciation: Drosophila reproductive tract proteins- twenty five years later. Singh R, et al. Int J Evol Biol, 2012. PMID 23119225, Free PMC Article
    4. Speciation and changes in male gene expression in Drosophila. Patlar B, et al. Genome, 2021 Feb. PMID 32730707
    5. Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS. Lacin H, et al. Elife, 2020 Mar 27. PMID 32216875, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    unc-4
    Names
    CG6269-PB
    CG6269-PC
    CG6269-PD
    paired HomeoDomain 1
    unc-4-PB
    unc-4-PC
    unc-4-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17768569..17778708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133014.3 → NP_573242.2  unc-4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573242.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77215, Q058S3
      UniProtKB/TrEMBL
      X2JFX5
      Conserved Domains (2) summary
      pfam00046
      Location:246 → 299
      Homeobox; Homeobox domain
      cl17190
      Location:327 → 368
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. NM_001298461.1 → NP_001285390.1  unc-4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285390.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCE2
      Conserved Domains (1) summary
      pfam00046
      Location:246 → 289
      Homeobox; Homeobox domain

    3. NM_001298460.1 → NP_001285389.1  unc-4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285389.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77215, Q058S3
      UniProtKB/TrEMBL
      X2JFX5
      Conserved Domains (2) summary
      pfam00046
      Location:246 → 299
      Homeobox; Homeobox domain
      cl17190
      Location:327 → 368
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77215.2 O77215
    X2JCE2 X2JCE2
    X2JFX5 X2JFX5

    Gene LinkOut

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