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    DhpD Dihydropterin deaminase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40528, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DhpDprovided by FlyBase
    Official Full Name
    Dihydropterin deaminaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261436
    Locus tag
    Dmel_CG18143
    See related
    AllianceGenome:FB:FBgn0261436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18143; Dmel\CG18143
    Summary
    Enables dihydropterin deaminase activity and guanine deaminase activity. Involved in dihydropteridine metabolic process; eye pigment biosynthetic process; and guanine metabolic process. Predicted to be active in cytosol. Is expressed in adult head; embryonic/larval fat body; and organism. Orthologous to human GDA (guanine deaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DhpD in Genome Data Viewer
    Location:
    82A1-82A1; 3-47.1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4227387..4229238, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (53109..54960, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beta-Mannosidase Neighboring gene uncharacterized protein Neighboring gene auxilin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene abstrakt

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin, a minor red eye pigment of Drosophila. Kim J, et al. J Biol Chem, 2009 Aug 28. PMID 19567870, Free PMC Article
    2. Biosynthesis of Pteridines in Insects: A Review. Ferré J. Insects, 2024 May 19. PMID 38786926, Free PMC Article
    3. The invertebrate growth factor/CECR1 subfamily of adenosine deaminase proteins. Charlab R, et al. Gene, 2001 Apr 4. PMID 11311551
    4. Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells. Ramirez J, et al. PLoS One, 2015. PMID 26460970, Free PMC Article
    5. SUMO-Enriched Proteome for Drosophila Innate Immune Response. Handu M, et al. G3 (Bethesda), 2015 Aug 18. PMID 26290570, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dihydropterin deaminase encoded by CG18143 plays a role in the biosynthesis of aurodrosopterin.
      Title: Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin, a minor red eye pigment of Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dihydropterin deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dihydropteridine metabolic process IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in dihydropteridine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye pigment biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in guanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in guanine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in guanine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dihydropterin deaminase
    Names
    CG18143-PA
    DhpD-PA
    NP_649439.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4227387..4229238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141182.3 → NP_649439.1  dihydropterin deaminase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649439.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMY9
      Related
      FBpp0078625
      Conserved Domains (1) summary
      cd01303
      Location:5 → 440
      GDEase; Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMY9.1 Q9VMY9

    Gene LinkOut

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