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    Prtl99C Protamine-like 99C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prtl99Cprovided by FlyBase
    Official Full Name
    Protamine-like 99Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039707
    Locus tag
    Dmel_CG15510
    See related
    AllianceGenome:FB:FBgn0039707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT14346; CG15510; Dmel\CG15510
    Summary
    Involved in sperm DNA condensation. Located in nucleus. Is expressed in male germline cell; seminal vesicle; and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prtl99C in Genome Data Viewer
    Location:
    99C2-99C3; 3-99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29835950..29837447)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25661672..25663169)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene neyo Neighboring gene Autophagy-related 16 Neighboring gene uncharacterized protein Neighboring gene Cadherin 99C Neighboring gene dim gamma-tubulin 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nejire/dCBP-mediated histone H3 acetylation during spermatogenesis is essential for male fertility in Drosophila melanogaster. Hundertmark T, et al. PLoS One, 2018. PMID 30192860, Free PMC Article
    2. Prtl99C Acts Together with Protamines and Safeguards Male Fertility in Drosophila. Eren-Ghiani Z, et al. Cell Rep, 2015 Dec 22. PMID 26673329
    3. The HMG-box-containing proteins tHMG-1 and tHMG-2 interact during the histone-to-protamine transition in Drosophila spermatogenesis. Gärtner SM, et al. Eur J Cell Biol, 2015 Jan. PMID 25464903
    4. A Testis-Specific Chaperone and the Chromatin Remodeler ISWI Mediate Repackaging of the Paternal Genome. Doyen CM, et al. Cell Rep, 2015 Nov 17. PMID 26549447
    5. Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila. Rathke C, et al. J Cell Sci, 2007 May 1. PMID 17452629

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in sperm DNA condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm DNA condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protamine-like 99C
    Names
    CG15510-PB
    CG15510-PC
    CG15510-PD
    Prtl99C-PB
    Prtl99C-PC
    Prtl99C-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29835950..29837447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143478.3 → NP_651735.3  Protamine-like 99C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651735.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JJ16, F2FB58, Q8MZC5, Q9VAF7
      Conserved Domains (1) summary
      pfam06382
      Location:1 → 125
      DUF1074; Protein of unknown function (DUF1074)

    2. NM_001300665.1 → NP_001287594.1  Protamine-like 99C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JJ16, F2FB58, Q8MZC5, Q9VAF7
      Conserved Domains (1) summary
      pfam06382
      Location:1 → 125
      DUF1074; Protein of unknown function (DUF1074)

    3. NM_001170300.2 → NP_001163771.1  Protamine-like 99C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163771.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VAF7
      Conserved Domains (1) summary
      pfam06382
      Location:1 → 117
      DUF1074; Protein of unknown function (DUF1074)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAF7.3 Q9VAF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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