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    Mms19 Mms19 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mms19provided by FlyBase
    Official Full Name
    Mms19provided by FlyBase
    Primary source
    FLYBASE:FBgn0037301
    Locus tag
    Dmel_CG12005
    See related
    AllianceGenome:FB:FBgn0037301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12005; Dmel\CG12005; dMMS19; mms19; MMS19; NEST:bs07f08
    Summary
    Involved in astral microtubule organization; mitotic nuclear division; and positive regulation of organelle organization. Located in several cellular components, including midbody; nucleus; and spindle microtubule. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; and mesoderm. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mms19 in Genome Data Viewer
    Location:
    82F6-82F6; 3-47.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5232543..5236288)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1058265..1062010)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 37B Neighboring gene Katanin 60 Neighboring gene retinophilin Neighboring gene Cathepsin F Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44019

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant. Queimado L, et al. Nucleic Acids Res, 2001 May 1. PMID 11328871, Free PMC Article
    2. Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells. Chippalkatti R, et al. PLoS Genet, 2020 Nov. PMID 33211700, Free PMC Article
    3. Microtubule-severing protein Katanin regulates neuromuscular junction development and dendritic elaboration in Drosophila. Mao CX, et al. Development, 2014 Mar. PMID 24550114
    4. Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase. Nag RN, et al. Development, 2018 Jan 25. PMID 29361561, Free PMC Article
    5. Drosophila retinophilin contains MORN repeats and is conserved in humans. Mecklenburg KL. Mol Genet Genomics, 2007 May. PMID 17285308

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells.
      Title: Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells.
    2. Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase.
      Title: Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic [4Fe-4S] assembly targeting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mms19
    Names
    CG12005-PB
    Mms19-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5232543..5236288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141262.3 → NP_649519.1  Mms19 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649519.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95U54, Q968K4
      Related
      FBpp0078425
      Conserved Domains (2) summary
      pfam12460
      Location:610 → 887
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:44 → 302
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95U54.1 Q95U54

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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