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    CG17739 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36333, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17739provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033710
    Locus tag
    Dmel_CG17739
    See related
    AllianceGenome:FB:FBgn0033710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0153538.35; CT39321; Dmel\CG17739
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in cell adhesion. Predicted to be active in extracellular matrix. Is expressed in eye and photoreceptor neurons. Orthologous to human SPON1 (spondin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17739 in Genome Data Viewer
    Location:
    48F6-48F7; 2-66 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12306528..12310412)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8194033..8197917)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene salto Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence that human genes of modular proteins have retained significantly more ancestral introns than their fly or worm orthologues. Bányai L, et al. FEBS Lett, 2004 May 7. PMID 15135065
    2. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. Xu Y, et al. J Cell Sci, 2016 Jan 15. PMID 26598556, Free PMC Article
    3. A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. Xu H, et al. EMBO J, 2004 Feb 25. PMID 14963491, Free PMC Article
    4. A single-cell atlas reveals unanticipated cell type complexity in Drosophila ovaries. Slaidina M, et al. Genome Res, 2021 Oct. PMID 34389661, Free PMC Article
    5. A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi. Fisher WW, et al. Genetics, 2023 Apr 6. PMID 36652461, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17739-PA
    Fat-spondin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12306528..12310412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136913.3 → NP_610757.1  uncharacterized protein Dmel_CG17739 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610757.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3Y9
      Related
      FBpp0087006
      Conserved Domains (5) summary
      smart00209
      Location:490 → 541
      TSP1; Thrombospondin type 1 repeats
      cd08544
      Location:23 → 163
      Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam00090
      Location:815 → 862
      TSP_1; Thrombospondin type 1 domain
      pfam06468
      Location:186 → 373
      Spond_N; Spondin_N
      cl00101
      Location:661 → 715
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3Y9 Q7K3Y9

    Gene LinkOut

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