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    rost rolling stone [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rostprovided by FlyBase
    Official Full Name
    rolling stoneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011705
    Locus tag
    Dmel_CG9552
    See related
    AllianceGenome:FB:FBgn0011705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9552; Dmel\CG9552
    Summary
    Involved in myoblast fusion. Located in membrane. Is expressed in several structures, including border follicle cell; embryonic brain; embryonic myoblast; head; and larval somatic muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rost in Genome Data Viewer
    Location:
    29F6-29F7; 2-34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8985936..8989539, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8985936..8989539, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene alien

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mesodermal expression of rolling stone (rost) is essential for myoblast fusion in Drosophila and encodes a potential transmembrane protein. Paululat A, et al. J Cell Biol, 1997 Jul 28. PMID 9230076, Free PMC Article
    2. The mutant not enough muscles (nem) reveals reduction of the Drosophila embryonic muscle pattern. Burchard S, et al. J Cell Sci, 1995 Apr. PMID 7615665
    3. Mergers and acquisitions: unequal partnerships in Drosophila myoblast fusion. Frasch M, et al. Cell, 2000 Jul 21. PMID 10943831
    4. Genetic analysis of myoblast fusion: blown fuse is required for progression beyond the prefusion complex. Doberstein SK, et al. J Cell Biol, 1997 Mar 24. PMID 9087441, Free PMC Article
    5. Fusion from myoblasts to myotubes is dependent on the rolling stone gene (rost) of Drosophila. Paululat A, et al. Development, 1995 Aug. PMID 7671823

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rolling stone
    Names
    CG9552-PA
    CG9552-PB
    CG9552-PC
    rost-PA
    rost-PB
    rost-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8985936..8989539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273345.1 → NP_001260274.1  rolling stone, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44252, Q5U0W2, Q95RK6, Q9VLF9
      UniProtKB/TrEMBL
      M9PD01
      Conserved Domains (1) summary
      pfam04750
      Location:52 → 254
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    2. NM_001273346.1 → NP_001260275.1  rolling stone, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260275.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44252, Q5U0W2, Q95RK6, Q9VLF9
      UniProtKB/TrEMBL
      M9PD01
      Conserved Domains (1) summary
      pfam04750
      Location:52 → 254
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    3. NM_164842.2 → NP_723435.1  rolling stone, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723435.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44252, Q5U0W2, Q95RK6, Q9VLF9
      UniProtKB/TrEMBL
      M9PD01
      Related
      FBpp0079382
      Conserved Domains (1) summary
      pfam04750
      Location:52 → 254
      Far-17a_AIG1; FAR-17a/AIG1-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD01 M9PD01
    O44252.2 O44252

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