Jra Jun-related antigen [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Jraprovided by FlyBase
Official Full Name: Jun-related antigenprovided by FlyBase
Primary source: FLYBASE:FBgn0001291
Locus tag: Dmel_CG2275
See related: AllianceGenome:FB:FBgn0001291
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Ap-1; AP-1; Ap1; AP1; c-Jun; CG2275; cjun; cJun; d-JRA; d-jun; d-Jun; D-jun; D-Jun; D-jun/Jra; D.Jun; dAP-1; dJra; dJRA; djun; dJun; dJUN; Djun; DJun; DJUN; dm-Jun; DM14; Dmel\CG2275; jra; JRA; jun; Jun; JUN; l(2)46Ef; l(2)IA109; l(2R)IA109; V
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and protein heterodimerization activity. Involved in several processes, including defense response to bacterium; egg chorion assembly; and imaginal disc fusion, thorax closure. Located in cytosol and nucleus. Part of transcription factor AP-1 complex. Is expressed in several structures, including amnioserosa primordium; dorsal ectoderm; epithelial cell; epithelium; and larval internal muscle motor neurons. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma; melanoma; and pulmonary tuberculosis. Orthologous to several human genes including JUNB (JunB proto-oncogene, AP-1 transcription factor subunit) and JUND (JunD proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 46E4-46E5; 2-62 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10096480..10098556)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5983985..5986061)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glial AP1 is activated with aging and accelerated by traumatic brain injury.
Title: Glial AP1 is activated with aging and accelerated by traumatic brain injury.
Mir-8 modulates Drosophila C virus replication by negative regulation of dJun.
Title: Drosophila microRNA modulates viral replication by targeting a homologue of mammalian cJun.
Tau and spectraplakin promote synapse formation and maintenance through Jun kinase and neuronal trafficking.
Title: Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking.
Jra recruits the HP1a/KDM4A complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation
Title: HP1a/KDM4A is involved in the autoregulatory loop of the oncogene gene c-Jun.
Data thus identify Atf3 as a new functional partner of Drosophila Jun during development.
Title: Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis.
AP-1 mediated synapse enhancement and its relationship to increases in synapse number, Ca2+ influx, Ca2+ sensitivity of vesicle fusion or synaptic vesicle number, were examined.
Title: Fos and Jun potentiate individual release sites and mobilize the reserve synaptic vesicle pool at the Drosophila larval motor synapse.
study of multisite phosphorylation
Title: A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun.
We observed complex genetic interactions between mnn1 and jun in different developmental settings. Our data support the idea that one function of menin is to modulate Jun activity in a manner dependent on the cellular context.
Title: Genetic interactions between Drosophila melanogaster menin and Jun/Fos.
Src, Jun N-terminal kinase, and STAT pathways are inhibited by Drosophila C-terminal Src kinase, which negatively regulates organ growth and cell proliferation
Title: Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.
AP1 acts as a repressor by recruiting the deacetylase complex to terminate activation of a group of NF-kappaB target genes
Title: Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R3/R4 cell fate commitment	TAS Traceable Author Statement more info	PubMed
involved_in chorion micropyle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation by host of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of antimicrobial humoral response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of antimicrobial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to steroid hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wound healing	HMP more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor AP-1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Jun-related antigen

Names: CG2275-PA; CG2275-PB; CG2275-PC; Jra-PA; Jra-PB; Jra-PC; Jun; Jun oncogene; Jun related antigen; activator protein 1; complementation group V; lethal(2)1A109; lethal(2)IA109

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

10096480..10098556

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165739.2 → NP_724882.1 Jun-related antigen, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724882.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P18289, Q0E9D8, Q9V5G4

Related

FBpp0087498

Conserved Domains (2) summary

cd14696
Location:214 → 274

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

pfam03957
Location:76 → 144

Jun; Jun-like transcription factor
NM_057238.5 → NP_476586.1 Jun-related antigen, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476586.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P18289, Q0E9D8, Q9V5G4

Related

FBpp0087499

Conserved Domains (2) summary

cd14696
Location:214 → 274

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

pfam03957
Location:76 → 144

Jun; Jun-like transcription factor
NM_001273915.2 → NP_001260844.1 Jun-related antigen, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260844.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEI6

Conserved Domains (2) summary

cd14696
Location:214 → 274

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

pfam03957
Location:76 → 144

Jun; Jun-like transcription factor