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    CG7560 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39276, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7560provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036157
    Locus tag
    Dmel_CG7560
    See related
    AllianceGenome:FB:FBgn0036157
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH18008; Dmel\CG7560; gh18008
    Summary
    Predicted to enable FAD binding activity and methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7560 in Genome Data Viewer
    Location:
    68C7-68C7; 3-36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11425158..11426395)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11418258..11419495)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44363 Neighboring gene long non-coding RNA:CR44548 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila. Nelson CS, et al. BMC Genomics, 2016 Nov 4. PMID 27809764, Free PMC Article
    2. GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise. Watanabe LP, et al. Sci Rep, 2021 Mar 4. PMID 33664357, Free PMC Article
    3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
    4. The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. Arancio W, et al. Genetics, 2010 May. PMID 20194965, Free PMC Article
    5. Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Zou S, et al. Proc Natl Acad Sci U S A, 2000 Dec 5. PMID 11095759, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylenetetrahydrofolate reductase (NAD(P)H) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7560-PA
    NP_648462.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11425158..11426395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140205.2 → NP_648462.1  uncharacterized protein Dmel_CG7560 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTI0
      Related
      FBpp0075903
      Conserved Domains (1) summary
      cd00537
      Location:76 → 331
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTI0 Q9VTI0

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