U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lds lodestar [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45894, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ldsprovided by FlyBase
    Official Full Name
    lodestarprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002542
    Locus tag
    Dmel_CG2684
    See related
    AllianceGenome:FB:FBgn0002542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2684; Dmel\CG2684; DmF2; Fs(3)Hor; Fs(3)Horka; Fs(3)Sz11; Horka; Lds; lod; NTef2
    Summary
    Enables ATP hydrolysis activity and ATP-dependent activity, acting on DNA. Involved in several processes, including DNA-templated transcription termination; female meiotic nuclear division; and microtubule anchoring at centrosome. Located in cytoplasm and nucleus. Is expressed in organism and ovary. Orthologous to human TTF2 (transcription termination factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lds in Genome Data Viewer
    Location:
    84E5-84E5; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7920431..7924491)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3746153..3750213)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA : MeU2-C41 Neighboring gene kipferl Neighboring gene uncharacterized protein Neighboring gene doublesex Neighboring gene CD98 heavy chain Neighboring gene Seminal fluid protein 84E Neighboring gene Os-C

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Fractionation of transcription factors for RNA polymerase II from Drosophila Kc cell nuclear extracts. Price DH, et al. J Biol Chem, 1987 Mar 5. PMID 3818640
    2. Purification of an RNA polymerase II transcript release factor from Drosophila. Xie Z, et al. J Biol Chem, 1996 May 10. PMID 8626643
    3. Drosophila factor 2, an RNA polymerase II transcript release factor, has DNA-dependent ATPase activity. Xie Z, et al. J Biol Chem, 1997 Dec 12. PMID 9395538
    4. Unusual nucleic acid binding properties of factor 2, an RNA polymerase II transcript release factor. Xie Z, et al. J Biol Chem, 1998 Feb 6. PMID 9452510
    5. Purification of P-TEFb, a transcription factor required for the transition into productive elongation. Marshall NF, et al. J Biol Chem, 1995 May 26. PMID 7759473

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated transcription termination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule anchoring at centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    lodestar
    Names
    CG2684-PA
    early-3
    early-5
    early-B
    factor 2
    female sterile (3) horka
    lds-PA
    negative transcription elongation factor 2
    transcript A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7920431..7924491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080111.4 → NP_524850.2  lodestar [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524850.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34739, Q9VHY1
      UniProtKB/TrEMBL
      A0A0C5K8A0
      Related
      FBpp0081255
      Conserved Domains (3) summary
      cd00046
      Location:459 → 634
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:885 → 1014
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:442 → 805
      SNF2_N; SNF2 family N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34739.2 P34739
    Q8MT27 Q8MT27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools