stl stall [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: stlprovided by FlyBase
Official Full Name: stallprovided by FlyBase
Primary source: FLYBASE:FBgn0086408
Locus tag: Dmel_CG3622
See related: AllianceGenome:FB:FBgn0086408
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GM08694; CG3622; Dmel\CG3622; fs(2)A16
Summary: Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Involved in follicle cell of egg chamber stalk formation and negative regulation of neuron migration. Predicted to be active in extracellular matrix. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome and geleophysic dysplasia 1. Orthologous to several human genes including ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10); ADAMTS16 (ADAM metallopeptidase with thrombospondin type 1 motif 16); and ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 59B2-59B2; 2-101 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22807860..22815993)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18695365..18703498)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that stl exhibits a strong mutant interaction with Delta (Dl), and Dl mutant ovaries show altered stl expression patterns.
Title: Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0887 (e-PCR)
- UniSTS:78334

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISM Inferred from Sequence Model more info	PubMed
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber stalk formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	HMP more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: stall

Names: CG3622-PC; CG3622-PE; female sterile(2)A16; stl-PC; stl-PE

NP_001097423.1

EC 3.4.24.-

NP_001246469.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22807860..22815993

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259540.1 → NP_001246469.1 stall, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246469.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W1Z6

Conserved Domains (4) summary

smart00209
Location:683 → 741

TSP1; Thrombospondin type 1 repeats

cd04273
Location:331 → 543

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:332 → 545

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:155 → 239

Pep_M12B_propep; Reprolysin family propeptide
NM_001103953.3 → NP_001097423.1 stall, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097423.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W1Z6

Conserved Domains (4) summary

smart00209
Location:683 → 741

TSP1; Thrombospondin type 1 repeats

cd04273
Location:331 → 543

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:332 → 545

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:155 → 239

Pep_M12B_propep; Reprolysin family propeptide