CG43066 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG43066provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0262476
Locus tag: Dmel_CG43066
See related: AllianceGenome:FB:FBgn0262476
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0149848.1; CG42510; CG43006; CG5226; Dmel\CG43066; Slc6a20
Old locus tag: Dmel_CG42510; Dmel_CG5226
Summary: Predicted to enable neurotransmitter:sodium symporter activity. Predicted to be involved in amino acid transport; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including CNS glial cell; adult head; embryonic central brain neurons; embryonic head sensory system; and ganglia. Human ortholog(s) of this gene implicated in Hartnup disease and autosomal recessive intellectual developmental disorder 48. Orthologous to several human genes including SLC6A15 (solute carrier family 6 member 15) and SLC6A17 (solute carrier family 6 member 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18514574..18526439)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14402079..14413944)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neurotransmitter:sodium symporter activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in glycine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter transport	ISM Inferred from Sequence Model more info	PubMed
involved_in neurotransmitter transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain