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    Dpp10 Dipeptidyl peptidase 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dpp10provided by FlyBase
    Official Full Name
    Dipeptidyl peptidase 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0031835
    Locus tag
    Dmel_CG11319
    See related
    AllianceGenome:FB:FBgn0031835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11319; Dmel\CG11319; DPP10
    Summary
    Enables dipeptidyl-peptidase activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in proteolysis and regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of Kv4.3-DPP10 channel complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asthma; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to several human genes including DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dpp10 in Genome Data Viewer
    Location:
    26E3-26F1; 2-21 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6568400..6601068, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6568400..6601068, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase subunit 5B-like Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene uncharacterized protein Neighboring gene Equilibrative nucleoside transporter 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44913 Neighboring gene Dpr-interacting protein iota

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster. Chihara CJ, et al. J Insect Sci, 2005 Nov 2. PMID 17119608, Free PMC Article
    2. Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity. Shiina Y, et al. Sci Rep, 2016 May 20. PMID 27198182, Free PMC Article
    3. Neuronal identity defines α-synuclein and tau toxicity. Praschberger R, et al. Neuron, 2023 May 17. PMID 36948206, Free PMC Article
    4. Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development. Carrera I, et al. Mol Cell Biol, 2008 Sep. PMID 18573871, Free PMC Article
    5. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. fly DPP10 is a dual functional protein, controlling Kv4 channel gating and removing bioactive peptides.
      Title: Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidyl-peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Kv4.3-DPP10 channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dipeptidyl peptidase 10
    Names
    CG11319-PA
    CG11319-PB
    CG11319-PC
    Dpp10-PA
    Dpp10-PB
    Dpp10-PC
    NP_001285682.1
    NP_001285683.1
    NP_609051.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6568400..6601068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135207.3 → NP_609051.1  dipeptidyl peptidase 10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMB4
      Related
      FBpp0088584
      Conserved Domains (3) summary
      COG1506
      Location:641 → 916
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:711 → 916
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:123 → 504
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. NM_001298754.1 → NP_001285683.1  dipeptidyl peptidase 10, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMB4
      Conserved Domains (3) summary
      COG1506
      Location:641 → 916
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:711 → 916
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:123 → 504
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    3. NM_001298753.1 → NP_001285682.1  dipeptidyl peptidase 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9P4
      Conserved Domains (3) summary
      COG1506
      Location:641 → 916
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:711 → 916
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:123 → 504
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMB4 Q9VMB4
    X2J9P4 X2J9P4

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