Mnt Mnt [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mntprovided by FlyBase
Official Full Name: Mntprovided by FlyBase
Primary source: FLYBASE:FBgn0023215
Locus tag: Dmel_CG13316
See related: AllianceGenome:FB:FBgn0023215
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bHLHe43; CG13316; CG2856; dMad; Dmel\CG13316; DmMnt; dmnt; dMnt; EG:114E2.2; Mad; Mad-3E; mnt; MNT
Summary: Enables protein heterodimerization activity and sequence-specific DNA binding activity. Involved in negative regulation of cell growth; negative regulation of transcription by RNA polymerase II; and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including epithelium; ganglia; head epidermis primordium; imaginal disc; and presumptive embryonic/larval system. Orthologous to human MNT (MAX network transcriptional repressor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 3E2-3E5; 1-4 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (3671801..3701672)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (3565834..3595705)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dMnt repression is normally overridden by dMyc activation during larval development.
Title: Drosophila growth and development in the absence of dMyc and dMnt.
dMnt is a transcriptional repressor that regulates D. melanogaster body size
Title: The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster.
Larval growth and endoreplication are coupled processes that, although linked to cell cycle control mechanisms, are regulated by dMyc and dMnt.
Title: dMyc is required for larval growth and endoreplication in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Mnt

Names: CG13316-PA; CG13316-PC; CG13316-PD; CG13316-PE; CG13316-PF; CG13316-PG; CG13316-PH; CG13316-PI; CG13316-PJ; CG13316-PK; Mnt-PA; Mnt-PC; Mnt-PD; Mnt-PE; Mnt-PF; Mnt-PG; Mnt-PH; Mnt-PI; Mnt-PJ; Mnt-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

3671801..3701672

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169180.1 → NP_001162651.1 Mnt, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162651.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W4Q7

Conserved Domains (1) summary

cd00083
Location:457 → 512

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001258583.2 → NP_001245512.1 Mnt, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245512.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NGP0

Conserved Domains (1) summary

cd00083
Location:457 → 512

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001169182.3 → NP_001162653.1 Mnt, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162653.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJE8

Conserved Domains (1) summary

cd00083
Location:457 → 512

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001169181.3 → NP_001162652.1 Mnt, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162652.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SY46, Q9W4Q8

Conserved Domains (1) summary

cd00083
Location:249 → 304

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_166984.3 → NP_726880.1 Mnt, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726880.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SY46, Q9W4Q8

Related

FBpp0070553

Conserved Domains (1) summary

cd00083
Location:249 → 304

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001169183.2 → NP_001162654.1 Mnt, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162654.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJD1

Conserved Domains (1) summary

cd00083
Location:248 → 303

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001297913.1 → NP_001284842.1 Mnt, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284842.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JDM5

Conserved Domains (1) summary

cd00083
Location:383 → 438

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001258584.2 → NP_001245513.1 Mnt, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245513.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NDN0

Conserved Domains (1) summary

cd00083
Location:249 → 304

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_130715.4 → NP_570071.3 Mnt, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_570071.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9W4Q7

Conserved Domains (1) summary

cd00083
Location:457 → 512

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_166983.3 → NP_726879.1 Mnt, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726879.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SY46, Q9W4Q8

Related

FBpp0070554

Conserved Domains (1) summary

cd00083
Location:249 → 304

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...