Tasp1 Taspase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tasp1provided by FlyBase
Official Full Name: Taspase 1provided by FlyBase
Primary source: FLYBASE:FBgn0263602
Locus tag: Dmel_CG5241
See related: AllianceGenome:FB:FBgn0263602
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.172; CG5241; Dmel\CG5241; dTasp; l(3)72Dl; Taspase1
Summary: Enables threonine-type endopeptidase activity. Involved in defense response to Gram-negative bacterium; protein processing; and spermatogenesis. Predicted to be active in cytoplasm. Is expressed in several structures, including larval muscle system; larval visceral muscle cell; trunk mesoderm; and visceral mesoderm derivative. Orthologous to human TASP1 (taspase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 72D1-72D4; 3-44 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16085221..16087525, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16078321..16080625, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the aim of the study was the detailed in vivo characterization and functional analysis of Drosophila Threonine Aspartase1 in order to dissect the evolutionary development of protease function.
Title: Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition.
Data demonstrate that the Drosophila homologs of mixed-lineage leukemia protein and host cell factor 1, called Trithorax and dHCF, are both cleaved by Drosophila taspase 1.
Title: Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables threonine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables threonine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables threonine-type endopeptidase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: taspase 1

Names: CG5241-PA; CG5241-PB; Tasp1-PA; Tasp1-PB; Taspase1; dTaspase1; drosophila threonine Aspartase1; lethal (3) 72Dl

NP_001261920.1

EC 3.-.-.-

EC 3.4.19.5

EC 3.4.25.-

EC 3.5.1.1

NP_648832.1

EC 3.-.-.-

EC 3.4.19.5

EC 3.4.25.-

EC 3.5.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

16085221..16087525 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274991.1 → NP_001261920.1 taspase 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261920.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95RX0, Q9VUX9

Conserved Domains (1) summary

cd04514
Location:3 → 364

Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
NM_140575.4 → NP_648832.1 taspase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648832.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95RX0, Q9VUX9

Related

FBpp0075253

Conserved Domains (1) summary

cd04514
Location:3 → 364

Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins