svr silver [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: svrprovided by FlyBase
Official Full Name: silverprovided by FlyBase
Primary source: FLYBASE:FBgn0004648
Locus tag: Dmel_CG4122
See related: AllianceGenome:FB:FBgn0004648
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv
Summary: Enables metallocarboxypeptidase activity and zinc ion binding activity. Involved in several processes, including long-term memory; neuropeptide processing; and positive regulation of actin filament polymerization. Located in perinuclear region of cytoplasm. Is expressed in several structures, including adult head; adult mushroom body; central nervous system; embryonic/larval corpus cardiacum; and embryonic/larval plasmatocyte. Orthologous to human CPD (carboxypeptidase D). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 1B5-1B7; 1-0 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (496446..509072)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (390479..403105)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila carboxypeptidase D (SILVER) is a key enzyme in neuropeptide processing required to maintain locomotor activity levels and survival rate.
Title: Drosophila carboxypeptidase D (SILVER) is a key enzyme in neuropeptide processing required to maintain locomotor activity levels and survival rate.
The carboxypeptidase D homolog silver regulates memory formation via insulin pathway in Drosophila.(
Title: The carboxypeptidase D homolog silver regulates memory formation via insulin pathway in Drosophila.
Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior.
Title: Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior.
DmCPD1Bs conforms to the structure of N/E-type funnelins/M14B metallopeptidases, but it has two unique structural elements potentially involved in regulation of its activity
Title: Structure-function analysis of the short splicing variant carboxypeptidase encoded by Drosophila melanogaster silver.
Data show that Drosophila S2 cells produce multiple forms of carboxypeptidase D with different intracellular distributions.
Title: Drosophila S2 cells produce multiple forms of carboxypeptidase D with different intracellular distributions.
The molecular basis for the phenotype of 3 carboxypeptidase D mutations are presented.
Title: Characterization of the molecular basis of the Drosophila mutations in carboxypeptidase D. Effect on enzyme activity and expression.
the Drosophila silver gene corresponds to a Carboxypeptidase D-like protein with three carboxypeptidase-like domains, a transmembrane domain, and a cytosolic tail
Title: Characterization of Drosophila carboxypeptidase D.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables carboxypeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed
located_in extracellular region	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: silver

Names: CG4122-PB; CG4122-PD; CG4122-PE; CG4122-PF; CG4122-PG; CG4122-PH; CG4122-PI; CG4122-PJ; CG4122-PL; CG4122-PM; CG4122-PN; DmSilver; carboxypeptidase; carboxypeptidase D; carboxypeptidase E; chlorotic; dwarp; pointed; svr-PB; svr-PD; svr-PE; svr-PF; svr-PG; svr-PH; svr-PI; svr-PJ; svr-PL; svr-PM; svr-PN

NP_001138141.1

EC 3.4.17.-

NP_001284742.1

EC 3.4.17.-

NP_001284743.1

EC 3.4.17.-

NP_001284744.1

EC 3.4.17.-

NP_525032.2

EC 3.4.17.-

NP_726675.3

EC 3.4.17.-

NP_788852.2

EC 3.4.17.-

NP_996319.1

EC 3.4.17.-

NP_996320.1

EC 3.4.17.-

NP_996321.1

EC 3.4.17.-

NP_996322.1

EC 3.4.17.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

496446..509072

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206599.2 → NP_996322.1 silver, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996322.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P42787

Conserved Domains (5) summary

cd03858
Location:454 → 757

M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like

cd11308
Location:336 → 414

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

pfam13620
Location:1221 → 1299

CarboxypepD_reg; Carboxypeptidase regulatory-like domain

pfam13715
Location:1123 → 1200

CarbopepD_reg_2; CarboxypepD_reg-like domain

cl11393
Location:35 → 332

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
NM_166846.5 → NP_726675.3 silver, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726675.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P42787

Conserved Domains (5) summary

cd03858
Location:454 → 757

M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like

cd11308
Location:336 → 414

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

pfam13620
Location:1221 → 1299

CarboxypepD_reg; Carboxypeptidase regulatory-like domain

pfam13715
Location:1123 → 1200

CarbopepD_reg_2; CarboxypepD_reg-like domain

cl11393
Location:35 → 332

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
NM_206598.3 → NP_996321.1 silver, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996321.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6AWJ5

Conserved Domains (2) summary

cd11308
Location:336 → 414

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

cl11393
Location:35 → 332

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
NM_001297813.1 → NP_001284742.1 silver, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284742.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6AWJ5

Conserved Domains (2) summary

cd11308
Location:336 → 414

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

cl11393
Location:35 → 332

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
NM_080293.4 → NP_525032.2 silver, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525032.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A2RVE4, B7Z112, C7LAH0, D0Z763, D3DME3, O46058, P42787, Q24094, Q24095, Q9W5F3, Q9W5F4, Q9W5F5

Related

FBpp0070080

Conserved Domains (5) summary

cd03858
Location:456 → 759

M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like

cd03868
Location:40 → 334

M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup

cd11308
Location:338 → 416

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

pfam13620
Location:1223 → 1301

CarboxypepD_reg; Carboxypeptidase regulatory-like domain

pfam13715
Location:1125 → 1202

CarbopepD_reg_2; CarboxypepD_reg-like domain
NM_206596.2 → NP_996319.1 silver, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996319.1

Status: REVIEWED

UniProtKB/TrEMBL

X2J9Z1

Conserved Domains (5) summary

cd03858
Location:456 → 759

M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like

cd03868
Location:40 → 334

M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup

cd11308
Location:338 → 416

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

pfam13620
Location:1223 → 1301

CarboxypepD_reg; Carboxypeptidase regulatory-like domain

pfam13715
Location:1125 → 1202

CarbopepD_reg_2; CarboxypepD_reg-like domain
NM_206597.2 → NP_996320.1 silver, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996320.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P42787

UniProtKB/TrEMBL

D3DME3

Conserved Domains (2) summary

cd11308
Location:338 → 416

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

cd03868
Location:40 → 334

M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
NM_176679.3 → NP_788852.2 silver, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788852.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A2RVE4, B7Z112, C7LAH0, D0Z763, D3DME3, O46058, P42787, Q24094, Q24095, Q9W5F3, Q9W5F4, Q9W5F5

Conserved Domains (5) summary

cd03858
Location:456 → 759

M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like

cd03868
Location:40 → 334

M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup

cd11308
Location:338 → 416

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

pfam13620
Location:1223 → 1301

CarboxypepD_reg; Carboxypeptidase regulatory-like domain

pfam13715
Location:1125 → 1202

CarbopepD_reg_2; CarboxypepD_reg-like domain
NM_001297815.1 → NP_001284744.1 silver, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284744.1

Status: REVIEWED

UniProtKB/TrEMBL

X2J9Z1

Conserved Domains (5) summary

cd03858
Location:456 → 759

M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like

cd03868
Location:40 → 334

M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup

cd11308
Location:338 → 416

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

pfam13620
Location:1223 → 1301

CarboxypepD_reg; Carboxypeptidase regulatory-like domain

pfam13715
Location:1125 → 1202

CarbopepD_reg_2; CarboxypepD_reg-like domain
NM_001144669.2 → NP_001138141.1 silver, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138141.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P42787

Conserved Domains (5) summary

cd03858
Location:309 → 612

M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like

cd11308
Location:191 → 269

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

pfam13620
Location:1076 → 1154

CarboxypepD_reg; Carboxypeptidase regulatory-like domain

pfam13715
Location:978 → 1055

CarbopepD_reg_2; CarboxypepD_reg-like domain

cl11393
Location:6 → 187

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
NM_001297814.1 → NP_001284743.1 silver, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284743.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P42787

UniProtKB/TrEMBL

D3DME3

Conserved Domains (2) summary

cd11308
Location:338 → 416

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

cd03868
Location:40 → 334

M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup