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    SMC3 Structural maintenance of chromosomes 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SMC3provided by FlyBase
    Official Full Name
    Structural maintenance of chromosomes 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0015615
    Locus tag
    Dmel_CG9802
    See related
    AllianceGenome:FB:FBgn0015615
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cap; Cap; CAP; CG9802; dCAP; Dmel\CG9802; DmSMC3; DmSMC3/Cap; dSMC3; smc3; Smc3
    Summary
    Predicted to enable chromatin binding activity; double-stranded DNA binding activity; and protein heterodimerization activity. Predicted to contribute to ATP hydrolysis activity. Involved in establishment of imaginal disc-derived wing hair orientation. Part of cohesin complex. Is expressed in organism and spermatozoon. Used to study Cornelia de Lange syndrome 3. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Orthologous to human SMC3 (structural maintenance of chromosomes 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See SMC3 in Genome Data Viewer
    Location:
    14F1-14F1; 1-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16588996..16593439, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16483029..16487472, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Calcineurin A at 14F Neighboring gene uncharacterized protein Neighboring gene Ubiquitin conjugating enzyme 7 Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 153kD Neighboring gene mir-4965 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromatin-associated cohesin turns over extensively and forms new cohesive linkages in Drosophila oocytes during meiotic prophase. Haseeb MA, et al. Curr Biol, 2024 Jul 8. PMID 38870933,
    2. Role of Securin, Separase and Cohesins in female meiosis and polar body formation in Drosophila. Guo Z, et al. J Cell Sci, 2016 Feb 1. PMID 26675236
    3. Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors. Perkins AT, et al. Proc Natl Acad Sci U S A, 2016 Nov 1. PMID 27791141, Free PMC Article
    4. Centromere Associations in Meiotic Chromosome Pairing. Da Ines O, et al. Annu Rev Genet, 2015. PMID 26421510
    5. Drosophila Yemanuclein associates with the cohesin and synaptonemal complexes. Meyer RE, et al. J Cell Sci, 2014 Nov 1. PMID 25189620

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of imaginal disc-derived wing hair orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    structural maintenance of chromosomes 3
    Names
    CG9802-PA
    Chromosome-associated protein
    SMC3-PA
    cohesin subunit SMC3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16588996..16593439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078650.3 → NP_523374.2  structural maintenance of chromosomes 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523374.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494K8, Q9VXE9
      Related
      FBpp0074065
      Conserved Domains (6) summary
      cd03272
      Location:3 → 159
      ABC_SMC3_euk; ATP-binding cassette domain of eukaryotic SMC3 proteins
      smart00968
      Location:533 → 643
      SMC_hinge; SMC proteins Flexible Hinge Domain
      pfam02463
      Location:2 → 1180
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam04420
      Location:780 → 822
      CHD5; CHD5-like protein
      pfam07851
      Location:678 → 760
      TMPIT; TMPIT-like protein
      cl21455
      Location:1088 → 1182
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24098 Q24098
    Q9VXE9 Q9VXE9

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