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    Ank2 Ankyrin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ank2provided by FlyBase
    Official Full Name
    Ankyrin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0261788
    Locus tag
    Dmel_CG42734
    See related
    AllianceGenome:FB:FBgn0261788
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ank2; ank2-L; CG18025; CG18227; CG18768; CG32373; CG32375; CG32377; CG34121; CG34158; CG34416; CG42734; CG7462; CG7493; dank2; Dank2; DAnk2; Dmel\CG42734; ESTS:149B10S; sp2523; SP2523
    Old locus tag
    CG32375; CG34121; CG34158; CG7462; Dmel_CG32375; Dmel_CG32377; Dmel_CG34121; Dmel_CG34158; Dmel_CG34416; Dmel_CG7462
    Summary
    Involved in several processes, including negative regulation of neuromuscular synaptic transmission; positive regulation of synaptic assembly at neuromuscular junction; and short-term memory. Located in neuromuscular junction; presynaptic periactive zone; and terminal bouton. Is expressed in several structures, including ganglia; nerve; neuromuscular junction; presumptive embryonic/larval system; and sensory neurons. Used to study Alzheimer's disease; epilepsy; and intellectual disability. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ank2 in Genome Data Viewer
    Location:
    66A8-66A10; 3-21 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7655389..7718395, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7648489..7711495, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SD Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Medium-chain acyl-CoA dehydrogenase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ankyrin Repeat Domain Controls Presynaptic Localization of Drosophila Ankyrin2 and Is Essential for Synaptic Stability. Weber T, et al. Front Cell Dev Biol, 2019. PMID 31475145, Free PMC Article
    2. Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration in Drosophila. Wodrich APK, et al. Biol Open, 2024 Jul 15. PMID 38912559, Free PMC Article
    3. The axonal localization of large Drosophila ankyrin2 protein isoforms is essential for neuronal functionality. Hortsch M, et al. Mol Cell Neurosci, 2002 May. PMID 12056839
    4. Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila. Schwartz S, et al. Mol Brain, 2023 May 16. PMID 37194019, Free PMC Article
    5. Control of axonal sprouting and dendrite branching by the Nrg-Ank complex at the neuron-glia interface. Yamamoto M, et al. Curr Biol, 2006 Aug 22. PMID 16920632

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila.
      Title: Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila.
    2. Expression of a portion of the C-terminal tail of the Ank2-L isoform of Ankyrin severely shortens the axon initial segment in Drosophila mushroom body (MB) neurons.
      Title: Expression of a Fragment of Ankyrin 2 Disrupts the Structure of the Axon Initial Segment and Causes Axonal Degeneration in Drosophila.
    3. We found that ddaE neurons have an axonal diffusion barrier proximal to the cell body that requires a giant isoform of the neuronal ankyrin Ank2. Furthermore, the potassium channel shal concentrates in the proximal axon in an Ank2-dependent manner
      Title: Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment.
    4. The heterotrimeric G protein Go functions as a transducer of Wingless-Frizzled 2 signaling in the synapse and Ankyrin 2 as a target of Go signaling required for neuromuscular junction formation
      Title: Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton.
    5. Ankyrin2 as a key presynaptic target of CK2.
      Title: Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2.
    6. Drosophila ankyrin 2 is required for synaptic stability.
      Title: Drosophila ankyrin 2 is required for synaptic stability.
    7. presynaptic Ank2-L lattice links synaptic membrane proteins and spectrin to the underlying microtubule cytoskeleton to organize and stabilize the presynaptic terminal.
      Title: A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic periactive zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin 2
    Names
    Ank2-PAA
    Ank2-PAB
    Ank2-PAC
    Ank2-PE
    Ank2-PF
    Ank2-PG
    Ank2-PJ
    Ank2-PK
    Ank2-PL
    Ank2-PM
    Ank2-PN
    Ank2-PP
    Ank2-PQ
    Ank2-PR
    Ank2-PS
    Ank2-PT
    Ank2-PU
    Ank2-PV
    Ank2-PW
    Ank2-PX
    Ank2-PY
    Ank2-PZ
    Ankyrin2 extra large
    CG42734-PAA
    CG42734-PAB
    CG42734-PAC
    CG42734-PE
    CG42734-PF
    CG42734-PG
    CG42734-PJ
    CG42734-PK
    CG42734-PL
    CG42734-PM
    CG42734-PN
    CG42734-PP
    CG42734-PQ
    CG42734-PR
    CG42734-PS
    CG42734-PT
    CG42734-PU
    CG42734-PV
    CG42734-PW
    CG42734-PX
    CG42734-PY
    CG42734-PZ
    Dank2
    SP2523
    ankyrin2
    ankyrin2-XL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7655389..7718395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300042.1 → NP_001286971.1  ankyrin 2, isoform Z [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286971.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JC49
      Conserved Domains (8) summary
      smart00218
      Location:1077 → 1180
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:514 → 639
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05403
      Location:23 → 158
      Plasmodium_HRP; Plasmodium histidine-rich protein (HRPII/III)
      pfam14755
      Location:2610 → 2687
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1567 → 1647
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:458 → 549
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:553 → 606
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:552 → 583
      ANK; ANK repeat [structural motif]

    2. NM_001274606.1 → NP_001261535.1  ankyrin 2, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEN3
      Conserved Domains (8) summary
      smart00218
      Location:1077 → 1180
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:514 → 639
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05403
      Location:23 → 158
      Plasmodium_HRP; Plasmodium histidine-rich protein (HRPII/III)
      pfam14755
      Location:2750 → 2827
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1567 → 1647
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:458 → 549
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:553 → 606
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:552 → 583
      ANK; ANK repeat [structural motif]

    3. NM_001414102.1 → NP_001401034.1  ankyrin 2, isoform AC [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0Y5

    4. NM_001104069.3 → NP_001097539.1  ankyrin 2, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097539.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNM5
      Conserved Domains (8) summary
      smart00218
      Location:1108 → 1211
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:514 → 639
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05403
      Location:23 → 158
      Plasmodium_HRP; Plasmodium histidine-rich protein (HRPII/III)
      pfam14755
      Location:2641 → 2718
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1598 → 1678
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:458 → 549
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:553 → 606
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:552 → 583
      ANK; ANK repeat [structural motif]

    5. NM_001202136.2 → NP_001189065.1  ankyrin 2, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRS5
      Conserved Domains (8) summary
      smart00218
      Location:1108 → 1211
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:514 → 639
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05403
      Location:23 → 158
      Plasmodium_HRP; Plasmodium histidine-rich protein (HRPII/III)
      pfam14755
      Location:2873 → 2950
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1598 → 1678
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:458 → 549
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:553 → 606
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:552 → 583
      ANK; ANK repeat [structural motif]

    6. NM_001202140.1 → NP_001189069.1  ankyrin 2, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189069.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS19
      Conserved Domains (7) summary
      smart00218
      Location:934 → 1037
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:371 → 496
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam14755
      Location:2607 → 2684
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1424 → 1504
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:315 → 406
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:410 → 463
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]

    7. NM_001202138.1 → NP_001189067.1  ankyrin 2, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189067.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSK6
      Conserved Domains (7) summary
      smart00218
      Location:965 → 1068
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:371 → 496
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam14755
      Location:2729 → 2806
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1455 → 1535
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:315 → 406
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:410 → 463
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]

    8. NM_001414101.1 → NP_001401033.1  ankyrin 2, isoform AB [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0Y4

    9. NM_168227.4 → NP_729285.3  ankyrin 2, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729285.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU92
      Conserved Domains (7) summary
      smart00218
      Location:927 → 1030
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam14755
      Location:2460 → 2537
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1417 → 1497
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    10. NM_001104066.2 → NP_001097536.1  ankyrin 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNM4
      Conserved Domains (6) summary
      smart00218
      Location:927 → 1030
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:1417 → 1497
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    11. NM_001104068.2 → NP_001097538.1  ankyrin 2, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097538.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNM6
      Conserved Domains (7) summary
      smart00218
      Location:927 → 1030
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam14755
      Location:2566 → 2643
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1417 → 1497
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    12. NM_001300041.1 → NP_001286970.1  ankyrin 2, isoform Y [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JGD3
      Conserved Domains (6) summary
      smart00218
      Location:927 → 1030
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:1417 → 1497
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    13. NM_001202139.1 → NP_001189068.1  ankyrin 2, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRR4
      Conserved Domains (7) summary
      smart00218
      Location:927 → 1030
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam14755
      Location:2600 → 2677
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1417 → 1497
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    14. NM_001202135.1 → NP_001189064.1  ankyrin 2, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189064.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRX1
      Conserved Domains (7) summary
      smart00218
      Location:927 → 1030
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam14755
      Location:2706 → 2783
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1417 → 1497
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    15. NM_001202141.1 → NP_001189070.1  ankyrin 2, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189070.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRX4
      Conserved Domains (7) summary
      smart00218
      Location:927 → 1030
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam14755
      Location:11936 → 12013
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1417 → 1497
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    16. NM_001300043.1 → NP_001286972.1  ankyrin 2, isoform AA [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286972.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCM1
      Conserved Domains (6) summary
      smart00218
      Location:927 → 1030
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:1417 → 1497
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    17. NM_001104065.2 → NP_001097535.1  ankyrin 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNM7
      Conserved Domains (7) summary
      smart00218
      Location:958 → 1061
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam14755
      Location:2491 → 2568
      ER-remodelling; Intracellular membrane remodeller
      cd08317
      Location:1448 → 1528
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    18. NM_139891.4 → NP_648148.2  ankyrin 2, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648148.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU95
      Conserved Domains (6) summary
      smart00218
      Location:927 → 1030
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08317
      Location:1417 → 1497
      Death_ank; Death domain associated with Ankyrins
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    19. NM_001274607.1 → NP_001261536.1  ankyrin 2, isoform W [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHP8
      Conserved Domains (5) summary
      smart00218
      Location:1077 → 1180
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:514 → 639
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:458 → 549
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:553 → 606
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:552 → 583
      ANK; ANK repeat [structural motif]

    20. NM_001104063.2 → NP_001097533.1  ankyrin 2, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097533.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NCP8
      Conserved Domains (5) summary
      smart00218
      Location:927 → 1030
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:209 → 300
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:403 → 456
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]

    21. NM_001104064.2 → NP_001097534.1  ankyrin 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097534.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3KN55
      Conserved Domains (4) summary
      cd00204
      Location:514 → 639
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:458 → 549
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:322 → 375
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:552 → 583
      ANK; ANK repeat [structural motif]

    22. NM_001274608.1 → NP_001261537.1  ankyrin 2, isoform X [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261537.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBV0
      Conserved Domains (4) summary
      cd00204
      Location:364 → 489
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:308 → 399
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:172 → 225
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNM4 A8JNM4
    A8JNM5 A8JNM5
    A8JNM6 A8JNM6
    A8JNM7 A8JNM7
    M9MRR4 M9MRR4
    M9MRS5 M9MRS5
    M9MRX1 M9MRX1
    M9MRX4 M9MRX4
    M9MS19 M9MS19
    M9MSK6 M9MSK6
    M9PBV0 M9PBV0
    M9PEN3 M9PEN3
    M9PHP8 M9PHP8
    Q3KN55 Q3KN55
    Q7KIS5 Q7KIS5
    Q7KU92 Q7KU92
    Q7KU95 Q7KU95
    Q8SWY2 Q8SWY2
    Q9I7Q8 Q9I7Q8
    Q9NCP8 Q9NCP8
    X2JC49 X2JC49
    X2JCM1 X2JCM1
    X2JGD3 X2JGD3

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