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    Sobp Sine oculis-binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sobpprovided by FlyBase
    Official Full Name
    Sine oculis-binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033654
    Locus tag
    Dmel_CG8991
    See related
    AllianceGenome:FB:FBgn0033654
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8991; Dmel\CG8991; Sbp; SOBP
    Summary
    Enables DNA-binding transcription factor binding activity. Involved in compound eye development. Predicted to be active in nucleus. Is expressed in border follicle cell; dorsal pharyngeal muscle cell; larval muscle system; larval somatic muscle cell; and larval visceral muscle cell. Orthologous to human SOBP (sine oculis binding protein homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sobp in Genome Data Viewer
    Location:
    48C4-48C4; 2-65 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11827170..11839825, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7714675..7727330, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene thisbe Neighboring gene Ionotropic receptor 48c Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44304 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene site-2 protease

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myogenesis control by SIX transcriptional complexes. Maire P, et al. Semin Cell Dev Biol, 2020 Aug. PMID 32247726
    2. Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development. Kenyon KL, et al. Dev Biol, 2005 Oct 1. PMID 16125693
    3. Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. Kenyon KL, et al. Dev Dyn, 2005 Nov. PMID 15937930
    4. Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network. Davis TL, et al. Fly (Austin), 2018 Jan 2. PMID 29125381, Free PMC Article
    5. Microarray analysis of the gene expression profiles of SL2 cells stimulated by LPS/PGN and curdlan. Jin LH, et al. Mol Cells, 2008 Jun 30. PMID 18460901

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sine oculis-binding protein
    Names
    CG8991-PA
    CG8991-PB
    Sobp-PA
    Sobp-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11827170..11839825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136859.3 → NP_610703.3  sine oculis-binding protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610703.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5X798, Q95TY2, Q9V620
      Related
      FBpp0087170
      Conserved Domains (2) summary
      pfam15279
      Location:278 → 587
      SOBP; Sine oculis-binding protein
      cl00909
      Location:275 → 312
      Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...

    2. NM_001299391.1 → NP_001286320.1  sine oculis-binding protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5X798, Q95TY2, Q9V620
      Conserved Domains (2) summary
      pfam15279
      Location:278 → 587
      SOBP; Sine oculis-binding protein
      cl00909
      Location:275 → 312
      Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TY2 Q95TY2

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